Interspecies molecular chimeras of kit help define the binding site of the stem cell factor
S Lev, J Blechman, SI Nishikawa, D Givol… - Molecular and cellular …, 1993 - Taylor & Francis
The extracellular portion of the kit-encoded receptor for the stem cell factor (SCF) comprises
five immunoglobulin (Ig)-like domains. To localize the ligand recognition site, we exploited …
five immunoglobulin (Ig)-like domains. To localize the ligand recognition site, we exploited …
Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation
T Tsujimura, T Furitsu, M Morimoto, K Isozaki… - 1994 - ashpublications.org
The c-kit proto-oncogene encodes a receptor tyrosine kinase that is known to play a crucial
role in hematopoiesis, especially in mast cell growth and differentiation. Although a number …
role in hematopoiesis, especially in mast cell growth and differentiation. Although a number …
A c-kit ligand, recombinant human stem cell factor, mediates reversible expansion of multiple CD34+ colony-forming cell types in blood and marrow of baboons
RG Andrews, SH Bartelmez, GH Knitter, D Myerson… - 1992 - ashpublications.org
The ligand for the human c-kit, recombinant human stem cell factor (SCF), was administered
to baboons at doses of 200, 100, 50, 25, and 10 micrograms/kg/d. SCF induced a dose …
to baboons at doses of 200, 100, 50, 25, and 10 micrograms/kg/d. SCF induced a dose …
Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group
PS Cohen, JP Chan, M Lipkunskaya, JL Biedler… - 1994 - ashpublications.org
During development, mice with mutations of stem cell factor (SCF) or its receptor c-kit exhibit
defects in melanogenesis, as well as hematopoiesis and gonadogenesis. Because …
defects in melanogenesis, as well as hematopoiesis and gonadogenesis. Because …
Human umbilical vein endothelial cells display high-affinity c-kit receptors and produce a soluble form of the c-kit receptor
VC Broudy, NL Kovach, LG Bennett, N Lin… - 1994 - ashpublications.org
Stem cell factor (SCF) is a hematopoietic growth factor produced by fibroblasts and
endothelial cells that stimulates the growth of primitive hematopoietic cells. SCF triggers cell …
endothelial cells that stimulates the growth of primitive hematopoietic cells. SCF triggers cell …
Stem cell factor as a survival and growth factor in human normal and malignant hematopoiesis
HT Hassan, A Zander - Acta haematologica, 1996 - karger.com
Stem cell factor (SCF) is an essential hematopoietic cytokine that interacts with other
cytokines to preserve the viability of hematopoietic stem and progenitor cells, to influence …
cytokines to preserve the viability of hematopoietic stem and progenitor cells, to influence …
[HTML][HTML] The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
The c-kit-encoded receptor protein tyrosine kinase for stem cell factor (Kit/SCF-R) is
essential for the development of cells within the hematopoietic, melanogenic and …
essential for the development of cells within the hematopoietic, melanogenic and …
[HTML][HTML] Proliferation of human myeloid leukemia cell line associated with the tyrosine-phosphorylation and activation of the proto-oncogene c-kit product
A Kuriu, H Ikeda, Y Kanakura, JD Griffin, B Druker… - Blood, 1991 - Elsevier
We investigated the expression, degree of phosphorylation, and activation of the proto-
oncogene c-kit product before and after stimulation with the c-kit ligand in a human factor …
oncogene c-kit product before and after stimulation with the c-kit ligand in a human factor …
Structure and regulation of Kit protein-tyrosine kinase—the stem cell factor receptor
R Roskoski Jr - Biochemical and biophysical research communications, 2005 - Elsevier
Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis,
hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human …
hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human …
The kit receptor and its ligand, steel factor, as regulators of hemopoiesis.
HE Broxmeyer, R Maze, K Miyazawa… - Cancer Cells (Cold …, 1991 - europepmc.org
Mouse strains carrying mutations at the Dominant White Spotting (W) locus or the Steel (Sl)
locus are anemic and display defects in pigmentation and gametogenesis. In W mutants the …
locus are anemic and display defects in pigmentation and gametogenesis. In W mutants the …