The c-kit proto-oncogene belongs to the tyrosine kinase receptor family. Although its ligand
is still unknown, there is increasing evidence to suggest its involvement in hematopoiesis. In …

Stem cell factor receptor (SCFR, c-kit), normally expressed on haematopoietic and mast
cells, plays a regulatory role in cellular growth and differentiation. Dysregulated expression …

To test the hypothesis that the c-kit ligand plays an important role in the regulation of early
events occurring during human hematopoiesis, we determined the effect of a recombinant …

The c-kit proto-oncogene encodes a receptor tyrosine kinase that is thought to play an
important role in hematopoiesis. In a series of human acute myeloblastic leukemia (AML) …

The c-kit proto-oncogene encodes the receptor for a novel hemopoietic cytokine, termed
stem cell factor (SCF) or mast cell growth factor (MGF) according to its stimulating spectrum …

Alternate splicing of mRNA encoding c-KIT results in isoforms which differ in the presence or
absence of four amino acids (GNNK) in the juxtamembrane region of the extracellular …

Stem cell factor (SCF) exerts its biological effects by binding to a specific receptor, the
tyrosine kinase c-Kit, which is expressed on the cell surface. Although normal cellular …

We have identified a novel growth factor, stem cell factor (SCF), for primitive hematopoietic
progenitors based on its activity on bone marrow cells derived from mice treated with …

Mast cells accumulate at sites of neovascularization, solid tumors, and many immune
reactions. Such accumulation requires directed migration of mature mast cells or their …

Mast cells (MC) are tissue elements derived from hematopoietic stem cells. Their
differentiation and proliferation processes are under the influence of cytokines, including …