Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo.

JJ Costa, GD Demetri, TJ Harrist, AM Dvorak… - The Journal of …, 1996 - rupress.org
Stem cell factor (SCF), also known as mast cell growth factor, kit ligand, and steel factor, is
the ligand for the tyrosine kinase receptor (SCFR) that is encoded by the c-kit proto …

Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor.

M Tsai, T Takeishi, H Thompson… - Proceedings of the …, 1991 - National Acad Sciences
We investigated the effects of a newly recognized multifunctional growth factor, the c-kit
ligand stem cell factor (SCF), on mouse mast cell proliferation and phenotype. Recombinant …

Candidate ligand for the c‐kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.

K Nocka, J Buck, E Levi, P Besmer - The EMBO journal, 1990 - embopress.org
The c‐kit proto‐oncogene encodes a transmembrane tyrosine kinase receptor for an
unidentified ligand and is allelic with the murine white‐spotting locus (W). W mutations affect …

Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding

B Tang, H Mano, T Yi, JN Ihle - Molecular and cellular biology, 1994 - Taylor & Francis
Stem cell factor (SCF) plays a crucial role in hematopoiesis through its interaction with the
receptor tyrosine kinase c-kit. However, the signaling events that are activated by this …

The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution …

M Tsai, LS Shih, GF Newlands, T Takeishi… - The Journal of …, 1991 - rupress.org
Mast cell development is a complex process that results in the appearance of phenotypically
distinct populations of mast cells in different anatomical sites. Mice homozygous for …

Expression of c-kit Receptor in Normal and Transformed Human Nonlymphoid Tissues

PG Natali, MR Nicotra, I Sures, E Santoro, A Bigotti… - Cancer research, 1992 - AACR
The protooncogene c-kit encodes a tyrosine kinase with a molecular weight of 145,000,
highly related to the platelet derived growth factor/colony stimulating factor receptors …

Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C.

P Blume-Jensen, L Rönnstrand, I Gout… - Journal of Biological …, 1994 - ASBMB
The Kit/stem cell factor receptor (Kit/SCF-R) is a transmembrane tyrosine kinase receptor of
importance for the normal development of hemopoietic cells, melanoblasts, and germ cells …

[PDF][PDF] activating hematopoietic stem cells

CL Miller, VI Rebel, ME Lemieux… - Experimental …, 1996 - academia.edu
Previous studies have suggested that Steel factor (SF) can influence the behavior of many
types of hematopoietic progenitor cells both in vivo and in vitro, although whether these may …

Activation of the human c‐kit product by ligand‐induced dimerization mediates circular actin reorganization and chemotaxis.

P Blume‐Jensen, L Claesson‐Welsh… - The EMBO …, 1991 - embopress.org
The proto‐oncogene c‐kit is allelic with the murine white spotting (W) locus and encodes a
transmembrane protein tyrosine kinase that is structurally related to the receptors for platelet …

Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro: effects of combination with colony-stimulating factors.

D Metcalf, NA Nicola - … of the National Academy of Sciences, 1991 - National Acad Sciences
Stem cell factor (SCF), the ligand for the c-kit protooncogene product, was able to stimulate
blast cell and granulocytic colony formation by precursors from normal murine bone marrow …