The proto‐oncogene c‐kit is allelic with the murine white spotting (W) locus and encodes a
transmembrane protein tyrosine kinase that is structurally related to the receptors for platelet …

Despite extensive research on the molecular mechanisms of signal transduction by growth
factors and their oncogenic receptor tyrosine kinases, the physiological relevance of these …

Tyrosine phosphorylation has a key role in intracellular signaling. Inappropriate proliferation
and survival cues in tumor cells often occur as a consequence of unregulated tyrosine …

Stem cell factor (SCF), the ligand for the c-kit protooncogene product, was able to stimulate
blast cell and granulocytic colony formation by precursors from normal murine bone marrow …

The c-Kit proto-oncogene is a receptor protein-tyrosine kinase associated with several
highly malignant human cancers. Upon binding its ligand, stem cell factor (SCF), c-Kit forms …

The murine Wand Steel loci encode the Kit receptor tyrosine kinase and its ligand, Steel
factor, respectively. Loss of function mutations at either the W or Sl loci lead to a variety of …

The c-kit proto-oncogene encodes a receptor tyrosine kinase that is crucial to
hematopoiesis, melanogenesis, and gametogeneis. Although the enzymatic activity of the c …

The expression and function of a receptor tyrosine kinase, c-kit, in the adult bone marrow of
the mouse were investigated by using monoclonal antibodies (mAbs) against the …

The Steel factor (SF) and its receptor c-Kit play a critical role for various cell types at different
levels in the hematopoietic hierarchy. Whether similar or distinct signaling pathways are …

Interaction of stem cell factor (SCF), a haematopoietic growth factor, with the receptor
tyrosine kinase c-kit leads to autophosphorylation of c-kit as well as tyrosine phosphorylation …