A major challenge in health care is the lack of knowledge about effects of multiple drug
treatment—polypharmacy—in old age. Randomized clinical trials typically exclude patients …

We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-
term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated …

Polypharmacy (use of≥ 5 drugs) is common in older people but has minimal preclinical or
clinical evidence of safety or efficacy and is associated with adverse outcomes in older …

Background: Polypharmacy (ie, the use of multiple medications and/or the administration of
more medications than are clinically indicated, representing unnecessary drug use) is …

As a result of continued advancement in medicine, more people are living longer. In 2014,
there were 46.3 million Americans (14.5%) who were at least 65 years old. This number is …

Polypharmacy is a major public health problem in the United States and abroad. Although
there is no standard definition of polypharmacy, I see and recognize it every day in the …

Background: Little information is available on the potential association between
polypharmacy and risk of mortality. Objective: To determine in a population-based study …

Introduction: Polypharmacy, defined as the use of multiple drugs or more than are medically
necessary, is a growing concern for older adults. MEDLINE and EMBASE databases were …

As individuals age, the likelihood of developing more than one chronic condition increases.
The presence of more than one disease, or multimorbidity, often leads to treatment with …

Background. Numerous methods have been used to evaluate medication management
quality in older adults; however, their predictive validities are unknown. Major medication …