Background There has been no definitive systematic review and meta-analysis to date
examining the effect of laxatives and pharmacological therapies in chronic idiopathic …

Objective To compare efficacy of pharmacotherapies for chronic idiopathic constipation
(CIC) based on comparisons to placebo using Bayesian network meta-analysis. Data …

Background There are several drugs available for the treatment of chronic idiopathic
constipation, but their relative efficacy is unclear because there have been no head-to-head …

BACKGROUND: Constipation is an uncomfortable and common condition that affects many,
irrespective of age. Since 1500 BC and before, health care practitioners have provided …

Introduction Chronic idiopathic constipation (CIC) is a common disorder associated with
significant impairment in quality of life. This clinical practice guideline, jointly developed by …

Background Although constipation can be a chronic and severe problem, it is largely treated
empirically. Evidence for the efficacy of some of the older laxatives from well‐designed trials …

Laxatives are commonly used to treat constipation and can be bought over-the-counter in
many countries, although some preparations need to be prescribed by physicians. A meta …

OBJECTIVES Constipation is common, and its treatment is unsatisfactory. Although many
agents have been tried, there are limited data to support their use. Our aim was to undertake …

Chronic constipation is a common functional gastrointestinal disorder that affects patients of
all ages. In 2007, a consensus group of 10 Canadian gastroenterologists developed a set of …

Background & Aims Several secretagogues have been approved for the treatment of irritable
bowel syndrome with constipation (IBS-C). However, their relative efficacy is unclear …