IL-4 promotes the development of Th2 cells and allergic inflammation. In atopic dermatitis
lesions, IL-4 decreases the expression of multiple genes associated with innate defense …

Background Atopic dermatitis (AD) is associated with epidermal barrier defects, dysbiosis,
and skin injury caused by scratching. In particular, the barrier-defective epidermis in patients …

The present study shows that human keratinocytes and skin express the receptor for TSLP.
We investigated whether TSLP is involved in filaggrin expression in primary human …

Atopic dermatitis (AD) is a chronic inflammatory skin disease known for its complex
pathophysiology involving several immune pathways. In the lesion, signals from barrier …

Skin fibrotic remodeling is a major feature in human atopic dermatitis (AD). Inflammation and
tissue fibrosis are common consequences of Th2 responses. Elevated IL-13 and thymic …

The pathogenesis of atopic dermatitis (AD) is understood to be crucially influenced by three
main factors: dysregulation of the immune response, barrier dysfunction, and pruritus. In the …

Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their
development. We show that human ILC2s express skin homing receptors and infiltrate the …

Innate lymphoid cells (ILCs) are a recently identified family of heterogeneous immune cells
that can be divided into three groups based on their differential developmental requirements …

Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2
(TH2)-type allergic inflammation is not known. We show here that human thymic stromal …

Thymic stromal lymphopoietin (TSLP) is an interleukin (IL) 7–like cytokine that triggers
dendritic cell–mediated T helper (Th) 2 inflammatory responses. TSLP is highly expressed …