Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling

S Nakajima, BZ Igyártó, T Honda, G Egawa… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: The clarification of cutaneous dendritic cell subset and the role of thymic
stromal lymphopoietin (TSLP) signaling in epicutaneous sensitization with protein antigens …

Critical role of TSLP receptor on CD4 T cells for exacerbation of skin inflammation

M Kitajima, M Kubo, SF Ziegler… - The Journal of …, 2020 - journals.aai.org
Thymic stromal lymphopoietin (TSLP) is a key cytokine that initiates and promotes allergic
inflammation both in humans and mice. It is well known that TSLP is important in initial step …

IL-17 receptor A maintains and protects the skin barrier to prevent allergic skin inflammation

A Floudas, SP Saunders, T Moran… - The Journal of …, 2017 - journals.aai.org
Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of
children and 3% of adults worldwide and is associated with dysregulation of the skin barrier …

[HTML][HTML] TNF-α and Th2 cytokines induce atopic dermatitis–like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents

MO Danso, V Van Drongelen, A Mulder… - Journal of Investigative …, 2014 - Elsevier
Atopic dermatitis (AD) is a chronic inflammatory skin disease in which the skin barrier
function is disrupted. In this inflammatory AD environment, cytokines are upregulated, but …

Opposing functions of thymic stromal lymphopoietin–responsive basophils and dendritic cells in a mouse model of atopic dermatitis

C Schwartz, JU Eberle, T Hoyler… - Journal of Allergy and …, 2016 - jacionline.org
To the Editor: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder
characterized by pruritic rash and scaly skin. It is further characterized by an inflammatory …

Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses

RP Larson, SC Zimmerli, MR Comeau… - The Journal of …, 2010 - journals.aai.org
Thymic stromal lymphopoietin (TSLP) is an IL-7–related cytokine, produced by epithelial
cells, that has been linked to atopic dermatitis and asthma; however, it remains unclear how …

[HTML][HTML] Non-IgE-reactive allergen peptides deteriorate the skin barrier in house dust mite-sensitized atopic dermatitis patients

K Pfisterer, M Wielscher, D Samardzic… - Frontiers in Cell and …, 2023 - frontiersin.org
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by type 2
cytokine-driven skin inflammation and epithelial barrier dysfunction. The latter is believed to …

Multiple-checkpoint inhibition of thymic stromal lymphopoietin–induced TH2 response by TH17-related cytokines

SI Bogiatzi, M Guillot-Delost, A Cappuccio… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: The interplay between allergy and autoimmunity has been a matter of long
debate. Epidemiologic studies point to a decreased frequency of allergy in patients with …

[HTML][HTML] Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis

LA Beck, MJ Cork, M Amagai, A De Benedetto… - JID Innovations, 2022 - Elsevier
Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

[HTML][HTML] IL-33 promotes gastrointestinal allergy in a TSLP-independent manner

H Han, F Roan, LK Johnston, DE Smith, PJ Bryce… - Mucosal …, 2018 - Elsevier
Atopic dermatitis (AD) often precedes asthma and food allergy, indicating that epicutaneous
sensitization to allergens may be important in the induction of allergic responses at other …