Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including
keratinocytes, and is important in allergic inflammation. Allergic skin inflammation elicited by …

Atopic dermatitis (AD) is a highly pruritic, chronic relapsing inflammatory skin disease
characterized by innate and adaptive immune reactions. In AD, innate immune mechanisms …

Background Atopic dermatitis (AD) is characterized by a skin barrier defect aggravated by
mechanical injury inflicted by scratching, a TH 2 cell–dominated immune response, and …

Genetic or vitamin D3‐induced overexpression of thymic stromal lymphopoietin (TSLP) by
keratinocytes results in an atopic dermatitis (AD)‐like inflammatory phenotype in mice …

Abstract Interleukin-4 (IL-4), a major T-helper type 2 (Th2) cytokine, primes dendritic cells
(DCs) for IL-12 production, suggesting a negative feedback loop to prevent dysregulated …

Background Targeting IL‐13 is highly efficacious in patients with Th2‐biased atopic
dermatitis (AD), but inhibition of other inflammatory molecules might also limit disease. We …

Atopic dermatitis (AD) is a common chronic skin disease with multiple pathogenic factors
including skin barrier dysfunction, immune abnormalities, and pruritus. This review …

Chronic inflammatory skin diseases are multifactorial diseases that combine genetic
predisposition, environmental triggers, and metabolic disturbances associated with …

Background Perturbation of epidermal barrier formation will profoundly compromise overall
skin function, leading to a dry and scaly, ichthyosis-like skin phenotype that is the hallmark of …

Allergic diseases are often triggered by environmental allergens that induce dominant type 2
immune responses, characterized by the infiltrated T‐helper type 2 (TH2) lymphocytes …