The discovery of innate lymphoid cells (ILC) has profoundly influenced the understanding of
innate and adaptive immune crosstalk in health and disease. ILC and T cells share …

The role of structural components and cell adhesion molecules in the epidermis has not
been fully studied in terms of the pathophysiology of atopic dermatitis (AD). In this issue …

Psoriasis is a common inflammatory skin disease, resulting from the interaction of genetic
and environmental triggers, leading to dysregulated immune response of innate and …

Atopic dermatitis (AD) is a chronic skin disease, which is associated with intense itch, skin
barrier dysfunction and eczematous lesions. Aberrant IL‐20 expression has been implicated …

Recombinant human IL‐2 has been used to treat inflammatory diseases and cancer;
however, side effects like skin rashes limit the use of this therapeutic. To identify key …

Human thymic stromal lymphopoietin (TSLP) is a novel epithelial cell–derived cytokine,
which induces dendritic cell (DC)-mediated CD4+ T cell responses with a proallergic …

Background While most studies focus on pro‐allergic cytokines, the protective role of
immunosuppressive cytokines in allergic inflammation is not well elucidated. This study was …

Highlights•ILC2 cells are potent effectors of type 2 inflammation.•ILC2 cells are present in
the skin and elevated and activated in atopic dermatitis.•ILC2 cells respond to epithelial …

Background Thymic stromal lymphopoietin (TSLP) is an extensively studied cytokine linked
to the pathogenesis of allergic diseases, but the inherent activities behind TSLP expression …

Resistance to apoptosis underpins the corticosteroid insensitivity of group 2 innate lymphoid
cells blocking antibody reduced secreted TSLP levels by approximately 35% in KtyI 2/2 cells …