Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2
PA Clark, S Llanos, G Peters - Oncogene, 2002 - nature.com
The small basic protein p14 ARF, encoded by one of the alternative transcripts from the
human INK4A/ARF locus, interferes with MDM2-mediated ubiquitination of the p53 tumour …
human INK4A/ARF locus, interferes with MDM2-mediated ubiquitination of the p53 tumour …
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
S Llanos, PA Clark, J Rowe, G Peters - Nature cell biology, 2001 - nature.com
The alternative product of the human INK4a/ARF locus, p14 ARF, has the potential to act as
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
The INK4a-ARF locus encodes two unrelated proteins that both function in tumor
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo
CA Midgley, JMP Desterro, MK Saville, S Howard… - Oncogene, 2000 - nature.com
The p53 tumour suppressor protein is down-regulated by the action of Mdm2, which targets
p53 for rapid degradation by the ubiquitin-proteasome pathway. The p14 ARF protein is also …
p53 for rapid degradation by the ubiquitin-proteasome pathway. The p14 ARF protein is also …
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53
The INK4a locus on chromosome 9p21 encodes two structurally distinct tumor suppressor
proteins, p16 INK4a and the alternative reading frame protein, ARF (p19 ARF in mouse and …
proteins, p16 INK4a and the alternative reading frame protein, ARF (p19 ARF in mouse and …
[HTML][HTML] Contribution of two independent MDM2-binding domains in p14ARF to p53 stabilization
MAE Lohrum, M Ashcroft, MHG Kubbutat, KH Vousden - Current Biology, 2000 - cell.com
The MDM2 protein targets the p53 tumor suppressor for ubiquitin-dependent degradation
[1], and can function both as an E3 ubiquitin ligase [2] and as a regulator of the subcellular …
[1], and can function both as an E3 ubiquitin ligase [2] and as a regulator of the subcellular …
Nucleolar Arf sequesters Mdm2 and activates p53
JD Weber, LJ Taylor, MF Roussel, CJ Sherr… - Nature cell …, 1999 - nature.com
Abstract The Ink4/Arf locus encodes two tumour-suppressor proteins, p16 Ink4a and p19 Arf,
that govern the antiproliferative functions of the retinoblastoma and p53 proteins …
that govern the antiproliferative functions of the retinoblastoma and p53 proteins …
Human p14ARF-mediated cell cycle arrest strictly depends on intact p53 signaling pathways
HO Weber, T Samuel, P Rauch, JO Funk - Oncogene, 2002 - nature.com
The tumor suppressor ARF is transcribed from the INK4a/ARF locus in partly overlapping
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo
Mdm2 has been shown to promote its own ubiquitination and the ubiquitination of the p53
tumour suppressor by virtue of its E3 ubiquitin ligase activity. This modification targets Mdm2 …
tumour suppressor by virtue of its E3 ubiquitin ligase activity. This modification targets Mdm2 …
Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis
L Moore, S Venkatachalam, H Vogel, JC Watt, CL Wu… - Oncogene, 2003 - nature.com
The p19 ARF gene product responds to oncogenic stresses by interfering with the inhibitory
effects of Mdm2 on p53, thus enhancing p53 activity and its antiproliferative functions. The …
effects of Mdm2 on p53, thus enhancing p53 activity and its antiproliferative functions. The …