Role of PHOSPHO1 in chondrocyte matrix vesicle mineralization: an AFM study Page 1 Role of
PHOSPHO1 in chondrocyte matrix vesicle mineralization: an AFM study M. Bottini,a,b, MC …

Abstract Background Matrix vesicles (MVs) are released from hypertrophic chondrocytes
and from mature osteoblasts, the cells responsible for endochondral and membranous …

Matrix vesicles have a critical role in the initiation of mineral deposition in skeletal tissues,
but the ways in which they exert this key function remain poorly understood. This issue is …

PHOSPHO1 is a phosphatase highly expressed in bone. We studied its functional
involvement in mineralization through the use of novel small molecule inhibitors …

Matrix vesicles (MVs) are involved in the initiation of mineralization in tissues undergoing
physiological and pathological calcification. Pyrophosphate (PPi) has a dual effect on …

Matrix-bound vesicles (MBVs) are embedded within osteoid and function as the site of initial
mineral formation. However, they remain insufficiently characterised in terms of biogenesis …

Mineralizing matrix vesicles (MVs) are extracellular organelles produced by chondrocytes,
osteoblasts, and odontoblasts under physiological conditions and by vascular smooth …

During the process of endochondral bone formation, chondrocytes and osteoblasts
mineralize their extracellular matrix by promoting the formation of hydroxyapatite seed …

We have previously shown that ablation of either the Phospho1 or Alpl gene, encoding
PHOSPHO1 and tissue‐nonspecific alkaline phosphatase (TNAP) respectively, lead to …

Extracellular vesicles (EV) are membrane-enclosed microstructures released from the cell.
EV can transport cargo—such as DNA, RNA, and proteins—into the extracellular space and …