The human hypoxia inducible factor 1 (HIF‐1) system is activated under various pathological
conditions, yet less is known about its physiological regulation in healthy human tissue. We …

Oxygen homeostasis is an essential regulation system for cell energy production and
survival. The oxygen-sensitive subunit α of the hypoxia inducible factor-1 (HIF-1) complex is …

New Findings What is the topic of this review? The role of hypoxia and, more specifically, the
role of the hypoxia‐sensitive transcription factor hypoxia‐inducible factor‐1 (HIF‐1) in …

This review summarizes the literature describing the significance of various conditions, such
as hypoxia, oxidative stress, and, above all, physical exercise, in the hypoxia-inducible …

During endurance training, exercising skeletal muscle experiences severe and repetitive
oxygen stress, and the muscle's ability to cope with and improve its function through that …

Regular exercise induces a variety of adaptive responses that enhance the oxidative and
metabolic capacity of human skeletal muscle. Although the physiological adjustments of …

During endurance training, exercising skeletal muscle experiences severe and repetitive
oxygen stress. The primary transcriptional response factor for acclimation to hypoxic stress is …

The physiological flux of oxygen is extreme in exercising skeletal muscle. Hypoxia is thus a
critical parameter in muscle function, influencing production of ATP, utilization of energy …

Skeletal muscle is a metabolically active tissue and the major body protein reservoir. Drop in
ambient oxygen pressure likely results in a decrease in muscle cells oxygenation, reactive …

Oxygen availability is crucial for cellular metabolism. Hypoxia-inducible factor 1 (HIF-1) is
the major oxygen homeostasis regulator. Under normoxic conditions, HIF-1 is rapidly …