Lipophilic dihydropyridines have many theoretical and practical clinical advantages owing to
their long permanence at the cell membrane. They have a greater chance of smoothly and …

Several types of calcium antagonists (CA)(verapamil, diltiazem, nifedipine and related
drugs) may be used as antihypertensives. In practice, the dihydropyridines (nifedipine and …

Aim: Lercanidipine, a long-acting dihydropyridine with a good antihypertensive efficacy and
tolerability in clinical use. With the aim to determine the efficacy and tolerability of this drug in …

Among the various drugs currently available for the treatment of systemic hypertension,
calcium antagonists continue to receive much attention because of their established efficacy …

Objective: To prospectively compare the individual tolerability of Lercanidipine (L) in
hypertensive patients with drug-specific side effects during the treatment with some …

Objective To evaluate the antihypertensive effect of lercanidipine once a day at three
different doses (2.5, 5 and 10 mg) by clinic and ambulatory blood pressure. Methods After 3 …

Lacidipine is a calcium antagonist of the dihydropyridine group that is highly selective for
vascular tissues. It has been tested during the last few years for the treatment of arterial …

Dihydropyridines are among the most widely used drugs for the management of
cardiovascular disease. Introduced in the 1960s, dihydropyridines have undergone several …

The efficacy and tolerability of lercanidipine, a new dihydropyridine calcium antagonist, were
assessed in comparison with atenolol in a randomized, double-blind, multicenter trial in …

Plasma drug concentration and hemodynamic responses to dihydropyridines correlate
closely. Differences in pharmacokinetic profile lead therefore to marked differences in blood …