Topoisomerase I is an ubiquitous DNA cleaving enzyme and an important therapeutic target
in cancer chemotherapy for the camptothecins as well as for indolocarbazole antibiotics …

Topoisomerase I is an ubiquitous DNA-cleaving enzyme and an important therapeutic target
in cancer chemotherapy for camptothecins as well as for indolocarbazole antibiotics such as …

Triple helix‐forming oligonucleotides covalently linked to topoisomerase I inhibitors, in
particular the antitumor agent camptothecin, trigger topoisomerase I‐mediated DNA …

To achieve a sequence-specific DNA cleavage by topoisomerase I, derivatives of the
antitumor drug camptothecin have been covalently linked to triple helix-forming …

There is considerable interest in the development of sequence-selective DNA drugs.
Chemical agents able to interfere with DNA topoisomerases-essential nuclear enzymes-are …

Indolocarbazole and benzopyridoquinoxaline derivatives have been shown to have anti-
tumor activity and to stimulate DNA topoisomerase I-mediated cleavage. Two …

The covalent linkage of a hairpin polyamide, which binds in the minor groove, to
camptothecin provides an efficient system to direct topoisomerase I mediated DNA cleavage …

Topoisomerase I is a ubiquitous DNA-cleaving enzyme and an important therapeutic target
in cancer chemotherapy for camptothecins (CPTs). These drugs stimulate DNA cleavage by …

Abstract Amsacrine-4-carboxamide-oligonucleotide conjugates were synthesized and
studied for their capacity to form DNA triple helices and to alter human topoisomerase II …

In the cell, DNA primarily exists in a supercoiled form and therefore unwinding of DNA is
required prior to using it for transcription, replication, or recombination. These functions …