Involvements of hyperhomocysteinemia in neurological disorders

M Cordaro, R Siracusa, R Fusco, S Cuzzocrea… - Metabolites, 2021 - mdpi.com
Homocysteine (HCY), a physiological amino acid formed when proteins break down, leads
to a pathological condition called hyperhomocysteinemia (HHCY), when it is over a definite …

[PDF][PDF] Hyperhomocysteinemia as a risk factor for the neuronal system disorders

M Petras, Z Tatarkova, M Kovalska, D Mokra… - J Physiol …, 2014 - academia.edu
Elevated concentration of the homocysteine (Hcy) in human tissues, resulting either from
mutations in genes enconding Hcy-metabolizing enzymes, or from deficiences of folic acid …

Hyperhomocysteinemia and neurologic disorders: a review

R Ansari, A Mahta, E Mallack… - Journal of clinical …, 2014 - synapse.koreamed.org
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine
metabolism. It has a physiologic role in DNA metabolism via methylation, a process …

[HTML][HTML] Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia

R Obeid, W Herrmann - FEBS letters, 2006 - Elsevier
Mild to moderate hyperhomocysteinemia is a risk factor for neurodegenerative diseases.
Human studies suggest that homocysteine (Hcy) plays a role in brain damage, cognitive and …

Homocysteine and brain atrophy

PS Sachdev - Progress in Neuro-Psychopharmacology and …, 2005 - Elsevier
Homocysteine (Hcy) has been implicated as a risk factor for vascular disease as well as
brain atrophy. There is evidence to implicate Hcy in increased oxidative stress, DNA …

Hyperhomocysteinemia: impact on neurodegenerative diseases

M Sharma, M Tiwari, RK Tiwari - Basic & clinical pharmacology …, 2015 - Wiley Online Library
Neurodegenerative diseases are the diseases of the central nervous system with various
aetiology and symptoms. Dementia, Alzheimer's disease (AD), Parkinson's disease (PD) …

Hyperhomocysteinemia: clinical insights

F Al Mutairi - Journal of central nervous system disease, 2020 - journals.sagepub.com
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, and intermediate metabolite
formed in metabolising methionine (Met) to cysteine (Cys); defective Met metabolism can …

The controversial role of homocysteine in neurology: from labs to clinical practice

R Moretti, P Caruso - International journal of molecular sciences, 2019 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine
metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin …

Homocysteine in neurology: a possible contributing factor to small vessel disease

R Moretti, M Giuffre, P Caruso, S Gazzin… - International Journal of …, 2021 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing amino acid generated during methionine
metabolism, accumulation of which may be caused by genetic defects or the deficit of …

Homocysteine: biochemistry, molecular biology and role in disease

A Hermann, G Sitdikova - Biomolecules, 2021 - mdpi.com
Homocysteine is a non-proteinogenic sulfhydryl-containing amino acid derived from
methionine and is a homologue of cysteine. The concentration of homocysteine is regulated …