Oxidative stress and inflammation in atrial fibrillation: role in pathogenesis and potential as a therapeutic target

DR Van Wagoner - Journal of cardiovascular pharmacology, 2008 - journals.lww.com
Atrial fibrillation (AF) is one of the most prevalent and vexing cardiovascular conditions.
Available treatments for AF based on ion channel blockade are only poorly effective. The …

Oxidant and inflammatory mechanisms and targeted therapy in atrial fibrillation: an update

A Gutierrez, DR Van Wagoner - Journal of cardiovascular …, 2015 - journals.lww.com
Atrial fibrillation (AF) is an important cause of stroke and risk factor for heart failure and
death. Current pharmacologic treatments for AF have limited efficacy, and treatments that …

The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation

P Korantzopoulos, TM Kolettis, D Galaris… - International journal of …, 2007 - Elsevier
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice
representing a major health hazard. Owing to relative inefficacy and side effects of classic …

Oxidative stress: a possible pathogenesis of atrial fibrillation

C Huang, Y Liu, W Xia, Y Tang, H Huang - Medical hypotheses, 2009 - Elsevier
Atrial fibrillation (AF) is the most commonly sustained arrhythmia in clinical practice. Despite
the extensive studies, the pathophysiology of AF, however, remains incompletely …

Mechanisms and treatments of oxidative stress in atrial fibrillation

X Ren, X Wang, M Yuan, C Tian, H Li… - Current …, 2018 - ingentaconnect.com
Atrial fibrillation (AF) is a frequent cardiac arrhythmia. It is a common major cause of serious
diseases and is an increasing health-care burden. AF is associated with an excess amount …

Role of inflammation in atrial fibrillation pathophysiology and management

M Harada, DR Van Wagoner, S Nattel - Circulation journal, 2015 - jstage.jst.go.jp
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia, but the methods
available for treating AF and its complications (of which the most important is …

Role of inflammatory signaling in atrial fibrillation

L Scott Jr, N Li, D Dobrev - International journal of cardiology, 2019 - Elsevier
Atrial fibrillation (AF), the most prevalent arrhythmia, is often associated with enhanced
inflammatory response. Emerging evidence points to a causal role of inflammatory signaling …

Inflammation and atrial fibrillation: a comprehensive review

P Korantzopoulos, KP Letsas, G Tse… - Journal of …, 2018 - Wiley Online Library
Atrial fibrillation (AF) has different underlying substrates. Atrial remodeling involves
electrophysiological and structural abnormalities that promote the development and …

Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins

AC Pinho-Gomes, S Reilly, RP Brandes… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Atrial fibrillation (AF) is a burgeoning health-care problem, and the currently
available therapeutic armamentarium is barely efficient. Experimental and clinical evidence …

Oxidative stress and atrial fibrillation: an update

P Korantzopoulos, K Letsas, N Fragakis… - Free Radical …, 2018 - Taylor & Francis
Atrial remodelling involves electrophysiological and structural abnormalities that promote
the development and perpetuation of atrial fibrillation. Experimental and clinical data …