E2F and Ras Synergize in Transcriptionally Activating p14ARF Expression
E Berkovich, Y Lamed, D Ginsberg - Cell Cycle, 2003 - Taylor & Francis
The INK4a/ARF locus, which is frequently inactivated in human tumors, encodes two distinct
tumor suppressive proteins, ARF and p16INK4a. ARF stabilizes and activates p53 by …
tumor suppressive proteins, ARF and p16INK4a. ARF stabilizes and activates p53 by …
Human ARF binds E2F1 and inhibits its transcriptional activity
B Eymin, L Karayan, P Séité, C Brambilla, E Brambilla… - Oncogene, 2001 - nature.com
The INK4a/ARF locus which is frequently inactivated in human tumours encodes two
different tumour suppressive proteins, p16 INK4a and ARF. p16 INK4a is a major component …
different tumour suppressive proteins, p16 INK4a and ARF. p16 INK4a is a major component …
p14ARF regulates E2F activity
SL Mason, OÈ Loughran, NB La Thangue - Oncogene, 2002 - nature.com
The ARF protein product of the ink4a/arf locus is induced by a variety of oncogenic signals.
ARF facilitates growth arrest through the p53 pathway by hindering the down-regulation of …
ARF facilitates growth arrest through the p53 pathway by hindering the down-regulation of …
Transcriptional regulation of the human tumor suppressor p14ARF by E2F1, E2F2, E2F3, and Sp1-like factors
T Parisi, A Pollice, A Di Cristofano, V Calabro… - Biochemical and …, 2002 - Elsevier
The human ARF/INK4a locus encodes two cell cycle inhibitors, p16INK4a and p14ARF, by
using separate promoters. A variety of mitogenic stimuli upregulate ARF but a direct …
using separate promoters. A variety of mitogenic stimuli upregulate ARF but a direct …
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
T Kamijo, JD Weber, G Zambetti… - Proceedings of the …, 1998 - National Acad Sciences
The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells
PG Hemmati, G Normand, B Verdoodt, C von Haefen… - Oncogene, 2005 - nature.com
The human INK4a locus encodes two structurally unrelated tumor suppressor proteins, p16
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
Human tumor suppressor ARF impedes S-phase progression independent of p53
WG Yarbrough, M Bessho, A Zanation, JE Bisi, Y Xiong - Cancer research, 2002 - AACR
Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated
proteins that both function in tumor suppression. p16INK4a maintains the retinoblastoma …
proteins that both function in tumor suppression. p16INK4a maintains the retinoblastoma …
p53-Dependent and-independent functions of the Arf tumor suppressor
CJ Sherr, D Bertwistle, W Den Besten… - Cold Spring Harbor …, 2005 - symposium.cshlp.org
Abstract The Ink4a-Arf locus encodes two closely wedded tumor suppressor proteins (p16
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …
Suppression of Ras-mediated NIH3T3 transformation by p19ARF does not involve alterations of cell growth properties
V Calabrò, T Parisi, AD Cristofano, G La Mantia - Oncogene, 1999 - nature.com
The INK4a gene, one of the most frequently disrupted loci in human cancer, encodes two
unrelated proteins, p16 INK4a and p19 ARF, that both block cell proliferation. p16 INK4a is a …
unrelated proteins, p16 INK4a and p19 ARF, that both block cell proliferation. p16 INK4a is a …
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
The INK4a-ARF locus encodes two unrelated proteins that both function in tumor
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …