Highlights•Genetic factors contribute to host variation in innate immune responses, response
eQTL.•Epigenetic marks are dynamically remodeled in response to immune challenges.• …

Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait
loci (eQTLs) and transcriptomes of monocytes from 215 individuals stimulated by fungal …

Immune response is one of the functions that have been more strongly targeted by natural
selection during human evolution. The evolutionary genetic dissection of the immune system …

Highlights•Mapping gene expression as a quantitative trait resolves functional regulatory
genetic variants.•Genomic modulators of immune gene expression are typically context …

A polymorphism modulating innate immunity signal transduction has recently been shown to
influence human susceptibility to many different infections, providing one more indication of …

Highlights•Host and pathogen genomes can be analyzed jointly.•Host and pathogen co-
evolution results in signals of positive selection.•Recent adaptation to pathogens generates …

The immune system plays a major role in human health and disease, and understanding
genetic causes of interindividual variability of immune responses is vital. Here, we isolate …

A growing body of evidence points towards epigenetic mechanisms being responsible for a
wide range of biological phenomena, from the plasticity of plant growth and development to …

Our understanding of the variation in individual clinical responses to pathogens has become
increasingly relevant, particularly in the face of new emerging epidemics as well as the …

Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …