CGH alterations in medullary thyroid carcinomas in relation to the RET M918T mutation and clinical outcome

T Frisk, J Zedenius, J Lundberg… - International …, 2001 - spandidos-publications.com
Apart from the RET proto-oncogene (RET) no other genes have been found to be involved in
medullary thyroid carcinoma (MTC) tumorigenesis. Germline RET mutations are seen …

Long-term outcomes and aggressiveness of hereditary medullary thyroid carcinoma: 40 years of experience at one center

F Raue, T Bruckner, K Frank-Raue - The Journal of Clinical …, 2019 - academic.oup.com
Context Recent data on long-term outcomes and aggressiveness of medullary thyroid
carcinoma (MTC) are lacking for patients with multiple endocrine neoplasia type 2 (MEN2) …

Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma

A Machens, H Dralle - World journal of surgery, 2007 - Springer
Background Since DNA tests have enabled reliable identification of asymptomatic RET
(rearranged during transfection) gene carriers, myriads of publications have appeared on …

[HTML][HTML] Familial medullary thyroid carcinoma: presymptomatic diagnosis and management in children

RA Heptulla, RP Schwartz, AE Bale, S Flynn… - The Journal of …, 1999 - Elsevier
Two kindreds with familial medullary thyroid carcinoma (MTC) are described in which
affected family members had variable clinical and pathologic manifestations. Genetic testing …

Medical management of metastatic medullary thyroid cancer

JE Maxwell, SK Sherman, TM O'Dorisio, JR Howe - Cancer, 2014 - Wiley Online Library
Medullary thyroid cancer (MTC) is an aggressive form of thyroid cancer that occurs in both
heritable and sporadic forms. Discovery that mutations in the rearranged during transfection …

Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis

MA Bartz-Kurycki, OE Oluwo… - … in endocrinology and …, 2021 - journals.sagepub.com
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that represents< 5% of all
thyroid malignancies and is generally more aggressive than differentiated thyroid cancer …

Early, prophylactic thyroidectomy in hereditary medullary thyroid carcinoma: a 26-year monoinstitutional experience

MR Pelizzo, F Torresan, IM Boschin… - American journal of …, 2015 - journals.lww.com
Purpose: Prophylactic thyroidectomy has been encouraged for children with REarranged
during Transfection (RET) germline mutations to prevent the onset, persistence, or …

Diagnostic challenges of medullary thyroid carcinoma

RD Leimbach, TD Hoang, MKM Shakir - Oncology, 2021 - karger.com
Background: Medullary thyroid carcinoma (MTC) comprises 1–2% of all thyroid cancers, yet
15% of all thyroid cancer-related deaths. While up to 20% of cases may be predicted due to …

Familial nonmedullary thyroid carcinoma

H Mazeh, RS Sippel - Thyroid, 2013 - liebertpub.com
Background: Nonmedullary thyroid cancers (NMTC) originate from the follicular cells of the
thyroid gland and account for over 90% of all thyroid cancers. About 3–10% of the NMTCs …

Medullary thyroid cancer: therapeutic targets and molecular markers

DW Ball - Current opinion in oncology, 2007 - journals.lww.com
Medullary thyroid cancer: therapeutic targets and molecular... : Current Opinion in Oncology
Medullary thyroid cancer: therapeutic targets and molecular markers : Current Opinion in …