Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via …

J Wan, G Kuang, L Zhang, R Jiang, Y Chen… - International …, 2020 - Elsevier
Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …

Kahweol Protects against Acetaminophen‐Induced Hepatotoxicity in Mice through Inhibiting Oxidative Stress, Hepatocyte Death, and Inflammation

JY Kim, J Leem, GM Kim - BioMed Research International, 2022 - Wiley Online Library
Acetaminophen (APAP) can cause acute liver failure, but treatment options are still limited.
Kahweol is the main diterpene compound of coffee and possesses antioxidant and anti …

Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2/STAT3 pathway and autophagy

W Zai, W Chen, J Luan, J Fan, X Zhang, Z Wu… - Applied microbiology …, 2018 - Springer
Acetaminophen (APAP) overdose is currently the leading cause of acute liver disease, but
therapeutic treatment strategies are commonly limited. Although dihydroquercetin (DHQ) is …

Protective effect of dihydrokaempferol on acetaminophen-induced liver injury by activating the SIRT1 pathway

J Zhang, C Hu, X Li, L Liang, M Zhang… - The American Journal …, 2021 - World Scientific
Acetaminophen (APAP) overdose is the leading cause of acute liver failure (ALF) in the
Western world, with limited treatment opportunities. 3, 5, 7, 4′-Tetrahydroxyflavanone …

[HTML][HTML] Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway

L Zhao, J Zhang, C Hu, T Wang, J Lu, C Wu… - Frontiers in …, 2020 - frontiersin.org
Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) is a
natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by …

Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress …

MS Tsai, YH Wang, YY Lai, HK Tsou, GG Liou, JL Ko… - Toxicology Letters, 2018 - Elsevier
Acetaminophen (APAP) overdose can induce acute liver injury (ALI) with significant
morbidity and mortality. Propacetamol is an APAP prodrug, which is clinically bioequivalent …

Glycyrrhetinic acid prevents acetaminophen-induced acute liver injury via the inhibition of CYP2E1 expression and HMGB1-TLR4 signal activation in mice

G Yang, L Zhang, L Ma, R Jiang, G Kuang, K Li… - International …, 2017 - Elsevier
Acetaminophen (APAP) is a widely used antipyretic and analgesic drug, which is safe and
effective at the therapeutic dose. Unfortunately, excessive dosage of APAP could cause …

Sesamin Protects against APAP‐Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal …

H Du, S Tong, G Kuang, X Gong… - Journal of …, 2023 - Wiley Online Library
Acetaminophen (APAP) overdose would lead to liver toxicity and even acute liver failure in
severe cases by triggering an inflammatory response and oxidative stress. Sesamin has …

[HTML][HTML] Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation

H Guo, J Sun, D Li, Y Hu, X Yu, H Hua, X Jing… - Biomedicine & …, 2019 - Elsevier
Acetaminophen (APAP) overdose causes acute liver injury and leads to fatal liver damage.
However, the therapies are quite limited. Shikonin is a natural product with antioxidant and …

[HTML][HTML] Attenuating oxidative stress by paeonol protected against acetaminophen-induced hepatotoxicity in mice

Y Ding, Q Li, Y Xu, Y Chen, Y Deng, F Zhi, K Qian - PLoS One, 2016 - journals.plos.org
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver
failure. The purpose of this study was to investigate whether paeonol protected against …