Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis
AA Wendel, TM Lewin, RA Coleman - … (BBA)-Molecular and Cell Biology of …, 2009 - Elsevier
Four homologous isoforms of glycerol-3-phosphate acyltransferase (GPAT), each the
product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3 …
product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3 …
Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria
TM Lewin, NMJ Schwerbrock, DP Lee… - Journal of Biological …, 2004 - ASBMB
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step of
glycerolipid synthesis. Two distinct GPAT isoenzymes had been identified in mammalian …
glycerolipid synthesis. Two distinct GPAT isoenzymes had been identified in mammalian …
Mammalian mitochondrial glycerol-3-phosphate acyltransferase
LK Dircks, HS Sul - Biochimica et Biophysica Acta (BBA)-Lipids and Lipid …, 1997 - Elsevier
Glycerol-3-phosphate acyltransferase (GPAT) is the first committed, and presumed to be a
rate-limiting, step in glycerophospholipid biosynthesis. There are two isoforms of GPAT, a …
rate-limiting, step in glycerophospholipid biosynthesis. There are two isoforms of GPAT, a …
Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity
RE Gimeno, J Cao - Journal of lipid research, 2008 - ASBMB
Glycerol-3-phosphate acyltransferases (GPATs; EC2. 3.1. 15) catalyze the first step in the de
novo synthesis of neutral lipids (triglycerides) and glycerophospholipids. The existence of …
novo synthesis of neutral lipids (triglycerides) and glycerophospholipids. The existence of …
Mitochondrial glycerol phosphate acyltransferase directs the incorporation of exogenous fatty acids into triacylglycerol
RA Igal, S Wang, M Gonzalez-Baró… - Journal of Biological …, 2001 - ASBMB
The mitochondrial isoform of glycerol-3-phosphate acyltransferase (GPAT), the first step in
glycerolipid synthesis, is up-regulated by insulin and by high carbohydrate feeding via …
glycerolipid synthesis, is up-regulated by insulin and by high carbohydrate feeding via …
Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
J Cao, JL Li, D Li, JF Tobin… - Proceedings of the …, 2006 - National Acad Sciences
Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de
novo synthesis of triacylglycerol. It has been well recognized that mammals possess multiple …
novo synthesis of triacylglycerol. It has been well recognized that mammals possess multiple …
Partial Purification and Properties of Glycerophosphate Acyltransferase from Rat Liver: Formation of 1‐Acylglycerol 3‐Phosphate from sn‐Glycerol 3‐Phosphate and …
S Yamashita, S Numa - European Journal of Biochemistry, 1972 - Wiley Online Library
1 Glycerophosphate acyltransferase was partially purified from rat‐liver microsomes which
were resolved with a nonionic detergent, Triton X‐100, in glycine buffer pH 8.6. The …
were resolved with a nonionic detergent, Triton X‐100, in glycine buffer pH 8.6. The …
Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity
AK Agarwal, RI Barnes, A Garg - Archives of biochemistry and biophysics, 2006 - Elsevier
Glycerophospholipids and triglycerides are synthesized de novo by cells through an
evolutionary conserved process involving serial acylations of phosphorylated glycerol …
evolutionary conserved process involving serial acylations of phosphorylated glycerol …
3 Enzymes of Triacylglycerol Formation in Mammals
RM Bell, RA Coleman - The enzymes, 1983 - Elsevier
Publisher Summary Triacylglycerol is suited to its role as the major storage fuel of mammals
as it provides 225% more calories per gram than glycogen and is not hydrated …
as it provides 225% more calories per gram than glycogen and is not hydrated …
Substrate channeling in the glycerol-3-phosphate pathway regulates the synthesis, storage and secretion of glycerolipids
J Lee, ND Ridgway - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2020 - Elsevier
The successive acylation of glycerol-3-phosphate (G3P) by glycerol-3-phosphate
acyltransferases and acylglycerol-3-phosphate acyltransferases produces phosphatidic acid …
acyltransferases and acylglycerol-3-phosphate acyltransferases produces phosphatidic acid …