Four homologous isoforms of glycerol-3-phosphate acyltransferase (GPAT), each the
product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3 …

Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step of
glycerolipid synthesis. Two distinct GPAT isoenzymes had been identified in mammalian …

Glycerol-3-phosphate acyltransferase (GPAT) is the first committed, and presumed to be a
rate-limiting, step in glycerophospholipid biosynthesis. There are two isoforms of GPAT, a …

Glycerol-3-phosphate acyltransferases (GPATs; EC2. 3.1. 15) catalyze the first step in the de
novo synthesis of neutral lipids (triglycerides) and glycerophospholipids. The existence of …

The mitochondrial isoform of glycerol-3-phosphate acyltransferase (GPAT), the first step in
glycerolipid synthesis, is up-regulated by insulin and by high carbohydrate feeding via …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de
novo synthesis of triacylglycerol. It has been well recognized that mammals possess multiple …

1 Glycerophosphate acyltransferase was partially purified from rat‐liver microsomes which
were resolved with a nonionic detergent, Triton X‐100, in glycine buffer pH 8.6. The …

Glycerophospholipids and triglycerides are synthesized de novo by cells through an
evolutionary conserved process involving serial acylations of phosphorylated glycerol …

Publisher Summary Triacylglycerol is suited to its role as the major storage fuel of mammals
as it provides 225% more calories per gram than glycogen and is not hydrated …

The successive acylation of glycerol-3-phosphate (G3P) by glycerol-3-phosphate
acyltransferases and acylglycerol-3-phosphate acyltransferases produces phosphatidic acid …