Human papillomavirus genome integration in squamous carcinogenesis: what have next‐generation sequencing studies taught us?

IJ Groves, N Coleman - The Journal of pathology, 2018 - Wiley Online Library
Human papillomavirus (HPV) infection is associated with∼ 5% of all human cancers,
including a range of squamous cell carcinomas. Persistent infection by high‐risk HPVs …

Multi‐omics data reveals novel impacts of human papillomavirus integration on the epigenomic and transcriptomic signatures of cervical tumorigenesis

X Zeng, Y Wang, B Liu, X Rao, C Cao… - Journal of Medical …, 2023 - Wiley Online Library
Integration of human papilloma virus (HPV) DNA into the human genome may progressively
contribute to cervical carcinogenesis. To explore how HPV integration affects gene …

A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques

C Ziegert, N Wentzensen, S Vinokurova, F Kisseljov… - Oncogene, 2003 - nature.com
Persistent infections with high-risk human papillomaviruses (HPVs) induce dysplastic
lesions of the lower genital tract. Some of these lesions eventually progress to invasive …

[HTML][HTML] Human papillomavirus type 16 integration analysis by real-time PCR assay in associated cancers

MHK Niya, H Keyvani, FS Tameshkel… - Translational …, 2018 - Elsevier
Human papillomavirus (HPV) is a common viral infection worldwide associated with a
variety of cancers. The integration of the HPV genome in these patients causes …

Genomic structures and regulation patterns at HPV integration sites in cervical cancer

VL Porter, K O'Neill, S MacLennan, RD Corbett, M Ng… - bioRxiv, 2023 - biorxiv.org
Human papillomavirus (HPV) integration has been implicated in transforming HPV infection
into cancer, but its genomic consequences have been difficult to study using short-read …

Human papilloma viruses and cervical tumours: mapping of integration sites and analysis of adjacent cellular sequences

E Klimov, S Vinokourova, E Moisjak, E Rakhmanaliev… - BMC cancer, 2002 - Springer
Background In cervical tumours the integration of human papilloma viruses (HPV) transcripts
often results in the generation of transcripts that consist of hybrids of viral and cellular …

Whole genome sequencing reveals complexity in both HPV sequences present and HPV integrations in HPV-positive oropharyngeal squamous cell carcinomas

G Gao, J Wang, JL Kasperbauer, NM Tombers, F Teng… - BMC cancer, 2019 - Springer
Background High risk human papillomaviruses (HPV) plays important roles in the
development of cervical cancer, a number of other anogenital cancer and they are …

Direct comparison of HPV16 viral genomic integration, copy loss, and structural variants in oropharyngeal and uterine cervical cancers reveal distinct relationships to …

TP Schrank, S Kim, H Rehmani, A Kothari, D Wu… - Cancers, 2022 - mdpi.com
Simple Summary HPV16 causes approximately 60% of uterine cervical cancer and 95% of
HPV-driven oropharynx cancers. Despite both being HPV-associated, these tumors are very …

Mapping and analysis of HPV16 integration sites in a head and neck cancer cell line

CCR Ragin, SC Reshmi… - International journal of …, 2004 - Wiley Online Library
Human papillomavirus (HPV) is a circular double‐stranded DNA virus implicated in at least
90% of cervical and anogenital cancers and has been observed in approximately 20% of …

[HTML][HTML] Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology

Y Liu, Z Lu, R Xu, Y Ke - Oncotarget, 2016 - ncbi.nlm.nih.gov
Integration of human papillomavirus (HPV) DNA into the host genome can be a driver
mutation in cervical carcinoma. Identification of HPV integration at base resolution has been …