Aims: Radiation-induced normal tissue toxicity often precludes the application of curative
radiation doses. Here we investigated the therapeutic potential of chemokine CC motif …

Patients receiving thoracic radiation often develop pulmonary injury and fibrosis. Currently,
there are no effective measures to prevent or treat these conditions. We tested whether …

Radiation-induced damage to normal lung parenchyma remains a dose-limiting factor in
thorax-associated radiotherapy (RT). Severe early and late complications with lungs can …

Lung exposure to radiation induces an injury response that includes the release of cytokines
and chemotactic mediators; these signals recruit immune cells to execute inflammatory and …

Radiation-induced lung toxicity, including radiation pneumonitis and pulmonary fibrosis,
often occurs in patients receiving radiation therapy. Epithelial-mesenchymal transition (EMT) …

Radiation-induced lung injury (RILI) is commonly observed in patients receiving
radiotherapy, and clinical prevention and treatment remain difficult. We investigated the …

Radiotherapy for cancer patients damages normal tissues, thereby inducing an inflammatory
response and promoting cancer metastasis. We investigated whether nicaraven, a …

Background A devastating late injury caused by radiation is pulmonary fibrosis. This risk
may limit the volume of irradiation and compromise potentially curative therapy. Therefore …

Radiation therapy is one of the primary treatments for thoracic malignancies, with radiation-
induced lung injury (RILI) emerging as its most prevalent complication. RILI encompasses …

Pulmonary fibrosis is caused by various known and unknown aetiologies, but the key
pathogenic mechanisms are still ill-defined. Chemokines are a large family of chemotactic …