Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay

S Tang, A Chen, X Zhou, L Zeng, M Liu, X Wang - Toxicology Letters, 2017 - Elsevier
Shikonin is a naphthoquinone pigment extracted from roots of Lithospermum erythrorhizon
Sieb. et Zucc.(Boraginaceae), and possesses various pharmaceutical activities, such as anti …

Investigation of cytochrome P450 inhibitory properties of deoxyshikonin, a bioactive compound from Lithospermum erythrorhizon Sieb. et Zucc

Y Zhang, J Gao, Y Xu, J Liu, S Huang, G Li… - Phytotherapy …, 2022 - Wiley Online Library
Deoxyshikonin, a natural naphthoquinone compound extracted from Lithospermum
erythrorhizon Sieb. et Z ucc (Boraginaceae), has a wide range of pharmacological activities …

Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach

A Chen, X Zhou, S Tang, M Liu, X Wang - Scientific Reports, 2016 - nature.com
Abstract Plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone), a natural naphthoquinone
compound isolated from roots of Plumbago zeylanica L., has drawn a lot of attention for its …

Potent inhibitory effect of alpha-viniferin on human cytochrome P450

J Sim, HW Jang, M Song, JH Kim, SH Lee… - Food and chemical …, 2014 - Elsevier
Abstract α-Viniferin isolated from Caragana chamlagu is a trimer of resveratrol, and has
several biological activities, which include anti-inflammatory, anti-oxidant, anti-arthritis, and …

Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells

SH Park, NM Phuc, J Lee, Z Wu, J Kim, H Kim… - Phytomedicine, 2017 - Elsevier
Background Acetylshikonin is one of the biologically active compounds derived from the root
of Lithospermum erythrorhizon, a medicinal plant with anti-cancer and anti-inflammation …

Evaluation of genipin on human cytochrome P450 isoenzymes and P-glycoprotein in vitro

LN Gao, Y Zhang, YL Cui, K Yan - Fitoterapia, 2014 - Elsevier
Genipin is obtained from the fruit of Gardenia jasminoides Ellis and acts as an herbal
medicine or functional food in East Asia. In addition to produce natural colorant, it possesses …

Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs

YL Han, D Li, B Ren, GP Jing, XL Meng… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Herba Erigerontis injection (HEI), one of the
most popular herbal prescription in China, is made from the aqueous extracts of Erigeron …

Species difference in the metabolism of mulberrin in vitro and its inhibitory effect on cytochrome P450 and UDP-glucuronosyltransferase enzymes

J Hu, T Hu, Z Guo, Y Song, L Shan… - Chemical and …, 2022 - jstage.jst.go.jp
This study aimed to evaluate the interspecies difference in metabolism of mulberrin and
examine the interaction between mulberrin and CYP enzymes or recombinant human …

Quasi-irreversible inhibition of CYP2D6 by berberine

HG Kim, HS Lee, JS Jeon, YJ Choi, YJ Choi, SY Yoo… - Pharmaceutics, 2020 - mdpi.com
In our previous study, Hwang-Ryun-Hae-Dok-Tang, which contains berberine (BBR) as a
main active ingredient, inhibited cytochrome P450 (CYP) 2D6 in a quasi-irreversible …

Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

Q Sun, T Gong, M Liu, S Ren, H Yang, S Zeng, H Zhao… - Phytomedicine, 2022 - Elsevier
Background Shikonin is one of the major phytochemical components of Lithospermum
erythrorhizon (Purple Cromwell), which is a type of medicinal herb broadly utilized in …