Activation of TRPM7 channels by small molecules under physiological conditions
T Hofmann, S Schäfer, M Linseisen, L Sytik… - … -European Journal of …, 2014 - Springer
Transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a cation
channel covalently linked to a protein kinase domain. TRPM7 is ubiquitously expressed and …
channel covalently linked to a protein kinase domain. TRPM7 is ubiquitously expressed and …
Mibefradil represents a new class of benzimidazole TRPM7 channel agonists
S Schäfer, S Ferioli, T Hofmann, S Zierler… - … -European Journal of …, 2016 - Springer
Transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a bi-
functional protein comprising an ion channel moiety covalently linked to a protein kinase …
functional protein comprising an ion channel moiety covalently linked to a protein kinase …
Mapping TRPM7 function by NS8593
V Chubanov, T Gudermann - International journal of molecular sciences, 2020 - mdpi.com
The transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a
ubiquitously expressed membrane protein, which forms a channel linked to a cytosolic …
ubiquitously expressed membrane protein, which forms a channel linked to a cytosolic …
Natural and synthetic modulators of the TRPM7 channel
V Chubanov, S Schäfer, S Ferioli, T Gudermann - Cells, 2014 - mdpi.com
Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a bi-
functional protein comprising a TRP ion channel segment linked to an α-type protein kinase …
functional protein comprising a TRP ion channel segment linked to an α-type protein kinase …
Assessment of TRPM7 functions by drug-like small molecules
V Chubanov, S Ferioli, T Gudermann - Cell calcium, 2017 - Elsevier
Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a plasma
membrane ion channel linked to a cytosolic protein kinase domain. Genetic inactivation of …
membrane ion channel linked to a cytosolic protein kinase domain. Genetic inactivation of …
9‐phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels
T Grand, M Demion, C Norez, Y Mettey… - British journal of …, 2008 - Wiley Online Library
Background and purpose: TRPM4 and TRPM5 are calcium‐activated non‐selective cation
channels with almost identical characteristics. TRPM4 is detected in several tissues …
channels with almost identical characteristics. TRPM4 is detected in several tissues …
Species-specific effects of cation channel TRPM4 small-molecule inhibitors
P Arullampalam, B Preti, D Ross-Kaschitza… - Frontiers in …, 2021 - frontiersin.org
Background: The Transient Receptor Potential Melastatin member 4 (TRPM4) gene
encodes a calcium-activated non-selective cation channel expressed in several tissues …
encodes a calcium-activated non-selective cation channel expressed in several tissues …
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition
Abstract The Ca2+-activated TRPM5 channel plays essential roles in taste perception and
insulin secretion. However, the mechanism by which Ca2+ regulates TRPM5 activity …
insulin secretion. However, the mechanism by which Ca2+ regulates TRPM5 activity …
TRPM8 channels: Advances in structural studies and pharmacological modulation
C Izquierdo, M Martín-Martínez… - International Journal of …, 2021 - mdpi.com
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …
Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain
R Takezawa, C Schmitz, P Demeuse… - Proceedings of the …, 2004 - National Acad Sciences
TRPM7 is a ubiquitously expressed and constitutively active divalent cation-selective ion
channel, whose basal activity is regulated by intracellular levels of Mg2+ and Mg· ATP. We …
channel, whose basal activity is regulated by intracellular levels of Mg2+ and Mg· ATP. We …