The majority of eukaryotic messenger RNA precursors (pre-mRNAs) undergo cleavage and
polyadenylation at their 3′ end. This canonical 3′-end processing depends on sequence …

Cleavage of nascent transcripts is a fundamental process for eukaryotic mRNA maturation
and for the production of different mRNA isoforms. In eukaryotes, cleavage of mRNA …

The 3′‐ends of almost all eukaryotic mRNAs are formed in a two‐step process, an
endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or …

Processing of mRNA precursors (pre-mRNAs) by polyadenylation is an essential step in
gene expression. Polyadenylation consists of two steps, cleavage and poly (A) synthesis …

Pre‐mRNA cleavage and polyadenylation is an essential step for 3′ end formation of
almost all protein‐coding transcripts in eukaryotes. The reaction, involving cleavage of …

Highlights•Integrated structural biology approaches have provided new insights into the
mechanism of eukaryotic mRNA 3′-end processing.•The polymerase modules of yeast and …

ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …

Poly (A) tails are present on almost all eukaryotic mRNAs, and play critical roles in mRNA
stability, nuclear export, and translation efficiency. The biosynthesis and shortening of a poly …

During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two‐step 3′‐
end processing reaction in which the pre‐mRNA is cleaved and released from the …

Pre-mRNA 3′ end formation is an essential step in eukaryotic gene expression. Over half of
human genes produce alternatively polyadenylated mRNAs, suggesting that regulated …