Cancer immunotherapies have rapidly changed the therapeutic landscape for cancer.
Nevertheless, most of the patients show innate or acquired resistance to these therapies …

Cancer immunotherapy has opened a new landscape in cancer treatment, however, the
poor specificity and resistance of most targeted therapeutics have limited their therapeutic …

The tumor microenvironment (TME) has been identified as one of the driving factors of tumor
progression and invasion. Within this microenvironment, cancer‐associated fibroblasts …

Cancer-associated fibroblasts (CAFs) are major protumorigenic components of the tumor
microenvironment in solid cancers. CAFs are heterogeneous, consisting of multiple subsets …

Immunotherapy for solid tumors has shown promise in preclinical as well as early clinical
studies. However, its efficacy remains limited. The hindrance to achieving objective, long …

Among all the stromal cells that present in the tumor microenvironment, cancer-associated
fibroblasts (CAFs) are one of the most abundant and critical components of the tumor …

Highlights•Tumor cells drive heterogeneous activation of cancer-associated fibroblasts
within the tumor microenvironment.•Fibroblast subpopulations within the TME can promote …

Cancer-associated fibroblasts (CAFs) are prominent components of the microenvironment in
most types of solid tumors, and were shown to facilitate cancer progression by supporting …

Cancer-associated fibroblasts (CAFs) are important, highly heterogeneous components of
the tumor extracellular matrix that have different origins and express a diverse set of …

Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …