Simple Summary Cancer-associated fibroblasts (CAFs) are key players in the tumor
microenvironment. They are responsible for potentiating growth and metastasis through …

Tumor microenvironment (TME) could impose a great challenge for cancer targeted
therapies. Immunosuppression within the TME creates a barrier between cancer cells and …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

The introduction of a wide range of immunotherapies in clinical practice has revolutionized
the treatment of cancer in the last decade. The majority of these therapeutic modalities are …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

In recent years, breakthroughs have been made in tumor immunotherapy. However, tumor
immunotherapy, particularly anti-PD-1/PD-L1 immune checkpoint inhibitors, is effective in …

Tumors are one of the main causes of death in humans. The development of safe and
effective methods for early diagnosis and treatment of tumors is a difficult problem that needs …

Simple Summary Cancer cells rely on the surrounding environment to grow and spread.
This environment contains structural components, secreted factors, immune cells, and other …

Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment
(TME) with diverse functions such as extracellular matrix (ECM) remodeling, modulation of …

Tumor-or cancer-associated fibroblasts (CAFs) are one of the most abundant stromal cell
types in different carcinomas and comprise a heterogeneous cell population. Classically …