Stromal cells in the tumor microenvironment (TME) closely interact with tumor cells and
affect tumor cell behavior in diverse manners. We herein investigated the mechanisms by …

Cancer microenvironment is created not only by malignant epithelial cells, but also by
several kinds of stromal cells. Since Paget proposed the “seed and soil” hypothesis, the …

Close interactions between cancer cells and cancer-associated fibroblasts (CAF) have
repeatedly been reported to support tumor progression. Yet, targeting CAFs has so far failed …

In the last decades, the role of the microenvironment in tumor progression and therapeutic
outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have …

Simple Summary An overwhelming percentage of deaths in solid tumors are caused by
treatment failure due to the disease's unresponsiveness when tumor cells tolerate treatment …

Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …

Human cancers exhibit formidable molecular heterogeneity, to a large extent accounting for
the incomplete and transitory efficacy of current anti-cancer therapies. However, neoplastic …

Inflammation is now established as a hallmark of cancer. Cancer‐associated fibroblasts
(CAFs) have been established as a key component of the crosstalk between tumour cells …

Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …

Understanding the spontaneous immune response of cancer patients is critical for the
design of efficient anticancer immunotherapies. The power of integrative tumor immunology …