Understanding the spontaneous immune response of cancer patients is critical for the
design of efficient anticancer immunotherapies. The power of integrative tumor immunology …

Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless,
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …

The prognosis for patients with cancers known for a highly activated stromal reaction,
including diffuse‐type (scirrhous) gastric cancer, consensus molecular subtype 4 (CMS4) …

Cancer-associated fibroblasts (CAFs) were originally presumed to represent a
homogeneous population uniformly driving tumorigenesis, united by their morphology and …

Tumor cells reside in a highly complex and heterogeneous tumor microenvironment (TME),
which is composed of a myriad of genetically stable non-cancer cells, including fibroblasts …

Cancer-associated fibroblasts (CAFs) are an integral component of the tumor
microenvironment and have both tumor-promoting and tumor-suppressive functions. This …

Stromal heterogeneity of tumor microenvironment (TME) plays a crucial role in malignancy
and therapeutic resistance. Cancer-associated fibroblasts (CAFs) are one of the major …

Cancer-associated fibroblasts (CAFs) are activated fibroblasts in the tumor
microenvironment. They are one of the most prominent cell types in the stroma and produce …

Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors
have successfully improved outcomes in several tumor types. In addition, currently, immune …

Background Local inflammation associated with solid tumors commonly results from factors
released by tumor cells and the tumor stroma, and promotes tumor progression. Cancer …