Tumor microenvironment has emerged as an important target for cancer therapy. In
particular, cancer-associated fibroblasts (CAF) seem to regulate many aspects of …

Owing to their tremendous diversity and plasticity, immune cells exert multifaceted functions
in tumor-bearing hosts, ranging from anti-tumor to pro-tumor activities. Tumor immune …

Cancer stem cells (CSCs) are broadly considered immature, multipotent, tumorigenic cells
within the tumor mass, endowed with the ability to self-renew and escape immune control …

Simple Summary Cell-to-cell communication between the immune system and tumors is of
the utmost importance; it influences the development of tumors, their growth, and how they …

Tumorigenesis is a complex process involving dynamic interactions between malignant cells
and their surrounding stroma, including both the cellular and acellular components. Within …

Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …

Simple Summary Breast cancer is a major public health problem with a large impact on the
life of patients and their families. It is a highly curable disease when detected early, and an …

Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …

Tumor-infiltrating immune cells (TIICs) are critical players in the tumor microenvironment,
modulating cancer cell functions. TIICs are highly heterogenic and plastic and may either …