Cortical state modulates the background activity of cortical neurons, and their evoked
response to sensory stimulation. Multiple mechanisms are involved in switching between …

Neurons of the nucleus locus coeruleus (LC) discharge with phasic bursts of activity
superimposed on highly regular tonic discharge rates. Phasic bursts are elicited by bottom …

Neuronal responses to sensory stimuli are not only driven by feedforward sensory pathways
but also depend upon intrinsic factors (collectively known as the network state) that include …

The brainstem nucleus locus coeruleus (LC) is the primary source of norepinephrine (NE) to
the mammalian neocortex. It is believed to operate as a homogeneous syncytium of …

Several previous studies have shown the existence of Up and Down states and have linked
their magnitude (eg, depolarization level) to the size of sensory-evoked responses. Here, we …

Chronic recording of locus coeruleus (LC) neurons in rat and monkey have pointed out that
brief, phasic LC discharges, but not sustained activity, are specifically related to salient …

It is believed that locus coeruleus (LC) influences the sensory information processing.
However, its role in cortical surround inhibitory mechanism is not well established. In this …

Ascending neuromodulatory projections from the locus coeruleus (LC) affect cortical neural
networks via the release of norepinephrine (NE). However, the exact nature of these …

Cortical neurons are organized in columns, distinguishable by their physiological properties
and input-output organization. Columns are thought to be the fundamental information …

Diffuse projections of locus coeruleus (LC) neurons and evidence of synchronous spiking
have long been perceived as features of global neuromodulation. Recent studies …