Multidimensional peptide separation will play an increasingly important role in the drive to
identify and quantitate the proteome. By increasing the peak and load capacity …

Current solution based proteomic analysis methods are generally based on enzymatic
digestion of a protein mixture followed by separation using multidimensional liquid …

Multidimensional liquid-based separation techniques are described for maximizing the
resolution of the enormous number of peptides generated upon tryptic digestion of …

Shotgun proteomics dominates the field of proteomics. The foundations of the strategy
consist of multiple rounds of peptide separation where chromatography provides the …

We have developed an effective two-dimensional fractionation protocol of complex
proteome mixtures that extends the ability to conduct more comprehensive proteome …

Proteomics is the study of all or part of the protein complement of genes in an organism,
often involving the analysis of complex protein/peptide samples. Such complex samples are …

Proteomics is the large-scale study of proteins, particularly their expression, structures and
functions. This still-emerging combination of technologies aims to describe and characterize …

Multidimensional protein identification technology (MudPIT)(1) developed as a method to
analyze the highly complex samples necessary for large-scale proteome analysis by …

Peptide fractionation is extremely important in proteomics approaches. Full proteome
characterization is desired from complex organisms, and with growing interest in post …

Multidimensional chromatography coupled to mass spectrometry is an emerging technique
for the analysis of complex protein mixtures. One approach in this general category …