Information-rich technologies have advanced personalized medicine, yet obstacles limit
measurement of large numbers of chemicals in human samples. Current laboratory tests …

Studies of gene–environment (G× E) interactions require effective characterization of all
environmental exposures from conception to death, termed the exposome. The exposome …

Analyzing metabolites (small molecules< 1 kDa) in body fluids such as urine and plasma
using various spectroscopic methods provides information on the metabotype (metabolic …

A number of recently developed mass spectrometry (MS)‐based metabolic fingerprinting
analyses are promoting metabolic analysis systems into practical clinical applications …

Metabolite profiling in biomarker discovery research requires new data preprocessing
approaches to correlate specific metabolites to their biological origin. Mass spectrometry …

Metabolite profiling has been established as a multiparallel strategy for relative
quantification of a mixture of compounds or compound classes using chromatography and …

Metabolite profiling in biomarker discovery, enzyme substrate assignment, drug
activity/specificity determination, and basic metabolic research requires new data …

Non-targeted metabolite profiling by ultra performance liquid chromatography coupled with
mass spectrometry (UPLC-MS) is a powerful technique to investigate metabolism. The …

The past decade has witnessed considerable advancements in sequencing technologies,
which have allowed comprehensive investigation of genetic variation of individuals at a …

Liquid chromatography coupled to mass spectrometry (LC-MS) is the gold standard in
bioanalysis for the development of quantitative assays to support drug development or …