Children with CKD are at increased risk for neurocognitive impairment, but whether
neurocognitive dysfunction is solely attributable to impaired renal function is unclear. Data …

Background The neuroanatomic basis for cognitive impairment in chronic kidney disease
(CKD) is incompletely characterized. We performed advanced quantitative structural …

Background: Whereas several longitudinal metabolomics studies have been conducted in
individuals with normal estimated glomerular filtration rate (eGFR) at baseline, disease …

Background Investigation of circulating metabolites associated with kidney function and
chronic kidney disease (CKD) risk could enhance our understanding of underlying pathways …

The purpose of the study was to explore associations between neurocognitive function and
chronic kidney disease (CKD)-related clinical characteristics. Twenty-nine children, ages 7 …

Metabolomic approaches have begun to catalog the metabolic disturbances that accompany
CKD, but whether metabolite alterations can predict future CKD is unknown. We performed …

Background The kidneys have a central role in the generation, turnover, transport, and
excretion of metabolites, and these functions can be altered in CKD. Genetic studies of …

Metabolomics, the latest of the “omics” sciences, refers to the systematic study of metabolites
and their changes in biological samples due to physiological stimuli and/or genetic …

Background In adult chronic kidney disease (CKD), metabolic acidosis is associated with
diminished cognition, notably executive function (EF). Data from the Chronic Kidney Disease …

Chronic kidney disease (CKD) in childhood is associated with neurocognitive deficits.
Affected children show worse performance on tests of intelligence than their unaffected …