Beyond the “at risk mental state” concept: transitioning to transdiagnostic psychiatry

PD McGorry, JA Hartmann, R Spooner… - World …, 2018 - Wiley Online Library
The “at risk mental state” for psychosis approach has been a catalytic, highly productive
research paradigm over the last 25 years. In this paper we review that paradigm and …

A critique of the “ultra‐high risk” and “transition” paradigm

J Van Os, S Guloksuz - World Psychiatry, 2017 - Wiley Online Library
The transdiagnostic expression of psychotic experiences in common mental disorder
(anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a …

[HTML][HTML] Pluripotential risk and clinical staging: theoretical considerations and preliminary data from a transdiagnostic risk identification approach

JA Hartmann, PD McGorry, L Destree… - Frontiers in …, 2021 - frontiersin.org
Most psychiatric disorders develop during adolescence and young adulthood and are
preceded by a phase during which attenuated or episodic symptoms and functional decline …

Broad clinical high‐risk mental state (CHARMS): Methodology of a cohort study validating criteria for pluripotent risk

JA Hartmann, B Nelson, R Spooner… - Early Intervention in …, 2019 - Wiley Online Library
Aim The development of the ultra‐high risk (UHR) criteria for psychosis created a new
paradigm for the prevention research in psychiatry. Since (1) prevention research faces the …

Prevalence of non-psychotic disorders in ultra-high risk individuals and transition to psychosis: a systematic review

U Albert, S Tomassi, G Maina, S Tosato - Psychiatry Research, 2018 - Elsevier
Despite the growing interest in the prodromes of psychosis, the proper identification of those
Ultra High Risk (UHR) subjects who will convert to psychosis remains an unresolved issue. It …

The psychosis high-risk state: a comprehensive state-of-the-art review

P Fusar-Poli, S Borgwardt, A Bechdolf… - JAMA …, 2013 - jamanetwork.com
Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

High remission rates from an initial ultra-high risk state for psychosis

AE Simon, D Umbricht - Schizophrenia research, 2010 - Elsevier
OBJECTIVE: To investigate the proportion of patients among subjects initially identified as
fulfilling the ultra-high risk (UHR) criteria for psychosis using the Scale of Prodromal …

Long-term follow-up of a group at ultra high risk (“prodromal”) for psychosis: the PACE 400 study

B Nelson, HP Yuen, SJ Wood, A Lin… - JAMA …, 2013 - jamanetwork.com
Importance The ultra high-risk (UHR) criteria were introduced to prospectively identify
patients at high risk of psychotic disorder. Although the short-term outcome of UHR patients …

Transition and remission in adolescents at ultra-high risk for psychosis

TB Ziermans, PF Schothorst, M Sprong… - Schizophrenia …, 2011 - Elsevier
BACKGROUND: Future success of early intervention initiatives to prevent the onset of
psychosis will rely on the validity of methods to predict clinical outcome. Proper identification …

Ultra high risk (UHR) for psychosis criteria: are there different levels of risk for transition to psychosis?

B Nelson, K Yuen, AR Yung - Schizophrenia research, 2011 - Elsevier
INTRODUCTION: The ultra high risk (UHR) for psychosis criteria have been validated in a
number of studies. However, it is not known whether particular UHR criteria (Attenuated …