Fetal overgrowth in pregnancies complicated by diabetes is the result of an increased
substrate availability which stimulates fetal insulin secretion and fetal growth. However …

The placenta is positioned between the maternal and fetal circulation and hence plays a key
role in transporting maternal nutrients to the developing fetus. Fetal growth changes in the 2 …

By its location between maternal and fetal bloodstreams the human placenta not only
handles the materno-fetal transport of nutrients and gases, but may also be exposed to …

Background: Gestational diabetes mellitus (GDM) is associated with increased fetal
adiposity, which may increase the risk of obesity in adulthood. The placenta has insulin …

The placenta represents the interface between the mother and fetus and delivers all the
nutrients necessary for normal fetal growth and development. Consequently, fetal growth is …

Gestational diabetes mellitus (GDM) is the most frequent pathophysiological state of
pregnancy, which in many cases produces fetuses with macrosomia, requiring increased …

In the adult, fine control of blood glucose concentration is accomplished through hormonal
control of glucose uptake and hepatic glucose production. In diabetes, however, the ability of …

Alterations in placental nutrient transfer have been implicated in fetal growth abnormalities.
In pregnancies complicated by diabetes and accelerated fetal growth, upregulations of …

Maternal obesity during pregnancy is rising and is associated with increased risk of
developing gestational diabetes mellitus (GDM), defined as glucose intolerance first …

Intrauterine growth restriction is associated with a range of alterations in placental transport
functions: the activity of a number of transporters is reduced (Systems A, L and Tau …