The acetylation state of histones plays a central role in determining gene expression in
chromatin. The reestablishment of the acetylation state of nucleosomes after DNA replication …

Nucleosome loss from a promoter region has recently been described as a potential
mechanism for transcriptional regulation. We investigated whether H3/H4 histone …

Summary Anti‐silencing function1 (ASF1) is an evolutionarily conserved histone chaperone.
Studies in yeast and animals indicate that ASF1 proteins play important roles in various …

Eukaryotic gene expression is regulated by histone deposition onto and eviction from
nucleosomes, which are mediated by several chromatin-modulating factors. Among them …

The HAT-B enzyme complex is responsible for acetylating newly synthesized histone H4 on
lysines K5 and K12. HAT-B is a multisubunit complex composed of the histone …

Following acetylation, newly synthesized H3-H4 is directly transferred from the histone
chaperone anti-silencing factor 1 (Asf1) to chromatin assembly factor 1 (CAF-1), another …

Asf1 is a conserved histone H3/H4 chaperone. We find that Asf1 in budding yeast promotes
an essential cellular response to replication stress caused by the ribonucleotide reductase …

The histone chaperone Asf1 and the checkpoint kinase Rad53 are found in a complex in
budding yeast cells in the absence of genotoxic stress. Our data suggest that this complex …

Maintenance of chromosomal integrity requires tight coordination of histone biosynthesis
with DNA replication. Here, we show that extracts from human cells exposed to replication …

The mammalian genome encodes multiple variants of histone H3 including H3. 1/H3. 2 and
H3. 3. In contrast to H3. 1/H3. 2, H3. 3 is enriched in the actively transcribed euchromatin …