[PDF][PDF] Immunodominance and functional alterations of tumor‐associated antigen‐specific CD8+ T‐cell responses in hepatocellular carcinoma

T Flecken, N Schmidt, S Hild, E Gostick… - …, 2014 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide with a poor
prognosis and limited therapeutic options. To aid the development of novel immunological …

[PDF][PDF] Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T‐regulatory cells

E Unitt, SM Rushbrook, A Marshall, S Davies… - …, 2005 - Wiley Online Library
Hepatocellular carcinoma (HCC) has a poor prognosis with limited therapeutic options. We
propose that local immune responses in patients with HCC are held in check by tumor …

[PDF][PDF] Comprehensive analysis of the α‐fetoprotein‐specific CD8+ T cell responses in patients with hepatocellular carcinoma

R Thimme, M Neagu, T Boettler… - …, 2008 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, with a
poor prognosis and limited therapeutic options. Therefore, the development of novel …

Strong CD8+ T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with hepatocellular carcinoma

K Hiroishi, J Eguchi, T Baba, T Shimazaki… - Journal of …, 2010 - Springer
Aim We investigated whether tumor-specific CD8+ T-cell responses affect tumor-free
survival as well as the relationship between CD8+ T-cell responses against tumor …

Naturally acquired MAGE-A10-and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma

G Bricard, H Bouzourene, O Martinet… - The Journal of …, 2005 - journals.aai.org
Immunotherapy is being proposed to treat patients with hepatocellular carcinoma (HCC).
However, more detailed knowledge on tumor Ag expression and specific immune cells is …

[PDF][PDF] Characteristics of immune response to tumor‐associated antigens and immune cell profile in patients with hepatocellular carcinoma

Y Inada, E Mizukoshi, T Seike, T Tamai, N Iida… - …, 2019 - Wiley Online Library
Host antitumor immune responses may be different between hepatocellular carcinoma
(HCC) caused by metabolic disorders and HCC associated with hepatitis virus infection. In …

Profile of tumor antigen-specific CD8 T cells in patients with hepatitis B virus-related hepatocellular carcinoma

AJ Gehring, ZZ Ho, AT Tan, MO Aung, KH Lee, KC Tan… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Tumor and viral antigens are expressed by hepatocellular
carcinoma (HCC) in patients with chronic hepatitis B, but little is known about the …

[HTML][HTML] Potential of immunotherapy for hepatocellular carcinoma

E Breous, R Thimme - Journal of hepatology, 2011 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with
limited therapeutic options. Since HCC has been shown to be immunogenic, T cell-based …

Increase of CD4á+ áCD25á+ á regulatory T-cells in the liver of patients with hepatocellular carcinoma

XH Yang, S Yamagiwa, T Ichida, Y Matsuda… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: The immune response to tumor-specific antigens is typically unable
to control the growth and spread of malignant cells. Accumulating evidence indicates that …

Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma

LA Ormandy, T Hillemann, H Wedemeyer, MP Manns… - Cancer research, 2005 - AACR
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide with a poor
prognosis and one for which immunotherapy remains a viable option. Experimental tumor …