Antiviral treatment down-regulates peripheral B-cell CD81 expression and CD5 expansion in chronic hepatitis C virus infection

E Zuckerman, A Kessel, G Slobodin, E Sabo… - Journal of …, 2003 - Am Soc Microbiol
Hepatitis C virus (HCV) infection is associated with immune-mediated abnormalities and B-
cell lymphoproliferation. Recently, CD81 was identified as an HCV receptor on B …

[PDF][PDF] Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti‐CD81 monoclonal antibody

C Ji, Y Liu, C Pamulapati, S Bohini, G Fertig… - …, 2015 - Wiley Online Library
CD81 is a required receptor for hepatitis C virus (HCV) infection of human hepatocytes in
vitro. We generated several high‐affinity anti‐human CD81 monoclonal antibodies (mAbs) …

Elevation of endoglin (CD105) concentrations in serum of patients with liver cirrhosis and carcinoma

E Yagmur, M Rizk, S Stanzel… - European journal of …, 2007 - journals.lww.com
Objective Liver cirrhosis is considered as a premalignant state, as about 80% of
hepatocellular carcinoma (HCC) is associated with liver cirrhosis. Although alpha …

Hepatitis C virus infection upregulates CD55 expression on the hepatocyte surface and promotes association with virus particles

B Mazumdar, H Kim, K Meyer, SK Bose… - Journal of …, 2013 - Am Soc Microbiol
ABSTRACT CD55 limits excessive complement activation on the host cell surface by
accelerating the decay of C3 convertases. In this study, we observed that hepatitis C virus …

High serum soluble CD155 level predicts poor prognosis and correlates with an immunosuppressive tumor microenvironment in hepatocellular carcinoma

AL Jin, YH Yang, X Su, WJ Yang, T Liu… - Journal of clinical …, 2022 - Wiley Online Library
Background Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies with
poor prognosis. There is no research about the clinical significance of serum soluble CD155 …

Determinants of CD81 dimerization and interaction with hepatitis C virus glycoprotein E2

HE Drummer, KA Wilson, P Poumbourios - Biochemical and biophysical …, 2005 - Elsevier
The tetraspanin CD81 plays an essential role in diverse cellular processes. CD81 also acts
as an entry receptor for HCV through an interaction between the large extracellular loop …

[PDF][PDF] Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C

K Kazankov, F Barrera, HJ Møller, BM Bibby… - …, 2014 - Wiley Online Library
Macrophages are involved in inflammation and liver fibrosis and soluble (s) CD163 is a
specific marker of activated macrophages. We investigated associations between sCD163 …

Serum levels of soluble CD30 in chronic hepatitis B virus infection

G Fattovich, F Vinante, G Giustina… - Clinical & …, 1996 - Wiley Online Library
There is evidence that both cellular and humoral components of the immune response are
required for viral clearance to occur in chronic hepatitis B. Recent studies demonstrated that …

Peripheral B-cell CD5 expansion and CD81 overexpression and their association with disease severity and autoimmune markers in chronic hepatitis C virus infection

E Zuckerman, G Slobodin, A Kessel… - Clinical & …, 2002 - academic.oup.com
Hepatitis C virus (HCV) infection is associated with immune-mediated abnormalities and B-
cell lymphoproliferation evolving to an overt lymphoma. Recently, CD81 was identified as an …

[HTML][HTML] Significance of palmitoylation of CD81 on its association with tetraspanin-enriched microdomains and mediating hepatitis C virus cell entry

YZ Zhu, Y Luo, MM Cao, Y Liu, XQ Liu, W Wang… - Virology, 2012 - Elsevier
CD81, a co-receptor for hepatitis C virus (HCV), is a member of the tetraspanin superfamily
and is heavily palmitoylated in the juxtamembrane cysteine residues. Palmitoylation plays …