Presenilin (PS1 and PS2) holoproteins are transiently incorporated into low molecular
weight (MW) complexes. During subsequent incorporation into a higher MW complex, they …

Presenilin (PS1 and PS2) holoproteins are transiently incorporated into low molecular
weight (MW) complexes. During subsequent incorporation into a higher MW complex, they …

Mutations in genes encoding presenilins (PS1 and PS2) cosegregate with the majority of
early onset cases of familial Alzheimer's disease. PS1 and PS2 are polytopic membrane …

Numerous mutations causing early onset Alzheimer's disease have been identified in the
presenilin (PS) genes, particularly the PS1 gene. Like the mutations identified within the β …

Presenilin 1 (PS1), mutated in pedigrees of early-onset familial Alzheimer's disease, is a
polytopic integral membrane protein that is endoproteolytically cleaved into 27-kDa N …

Mutations on human presenilins 1 and 2 cause dominant early-onset familial Alzheimer's
disease (FAD). Presenilins are polytopic transmembrane proteins endoproteolytically …

Humans inheriting missense mutations in thepresenilin (PS) 1 and-2 genes undergo
progressive cerebral deposition of the amyloid β-protein at an early age and develop a …

Mutations in the presenilin (PS) genes are linked to early onset familial Alzheimer's disease
(FAD). PS-1 proteins are proteolytically processed by an unknown protease to two stable …

Mutations in two related genes, presenilin 1andpresenilin 2 (PS1andPS2), cosegregate with
Alzheimer's disease. PS1 and PS2 are highly homologous polytopic membrane proteins that …

The mechanisms by which mutations in presenilin-1 (PS1) and presenilin-2 (PS2) result in
the Alzheimer's disease phenotype are unclear. Full-length PS1 and PS2 are each …