Introduction Severe sepsis is characterized by an initial hyper-inflammatory response that
may progress to an immune-suppressed state associated with increased susceptibility to …

Background Sepsis is a leading cause of mortality and critical illness worldwide and is
associated with an increased mortality rate in the months following hospital discharge. The …

Introduction Although major changes of the immune system have been described in sepsis,
it has never been studied whether these may differ in relation to the type of underlying …

Introduction Sepsis-induced immunosuppression may result in death. The mechanisms of
immune suppression include loss of macrophage and monocyte expression of the major …

Introduction Our aim was to define early changes of lymphocytes and of NK cells in severe
sepsis and to correlate them with serum levels of soluble triggering receptor expressed on …

Introduction During the course of infection, natural killer (NK) cells contribute to innate
immunity by producing cytokines, particularly interferon-gamma (IFN-γ). In addition to their …

Background Early survival following severe injury has been improved with refined
resuscitation strategies. Multiple organ dysfunction syndrome (MODS) is common among …

Purpose The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill
patients remains an understudied area. Previous studies have identified that acute tubular …

Background Although the immune function of neutrophils in sepsis has been well described,
the heterogeneity of neutrophils remains unclear during the process of sepsis. Methods In …

Introduction Given the pivotal role of T lymphocytes in the immune system, patients with
septic shock may show T cell abnormalities. We have characterised the T cell compartment …