The orthosteric γ-aminobutyric acid B (GABA B) receptor agonist baclofen is currently
considered a therapeutic option for alcohol use disorder (AUD); however, the safety profile …

Aims The effects of alcohol on gamma-aminobutyric acid (GABA) transmission are key for
the development and maintenance of alcohol use disorder (AUD). Previous research …

Accumulating lines of experimental and clinical evidence suggest that the prototypic,
orthosteric GABA type B (GABA B) receptor agonist, baclofen, may possess therapeutic …

The present paper summarizes experimental and clinical data suggesting the therapeutic
potential of the prototypic GABAB receptor agonist, baclofen, for the treatment of alcohol-use …

The present paper summarizes the preclinical and clinical studies conducted to define the
“anti-alcohol” pharmacological profile of the prototypic GABAB receptor agonist, baclofen …

Rationale A promising pharmacotherapy for alcohol use disorders has been positive
allosteric modulators (PAMs) of the γ-aminobutyric acid receptor B (GABA BR) since GABA …

The present paper summarizes experimental data demonstrating the reducing effect of direct
agonists and positive allosteric modulators (PAMs) of the γ-aminobutyric acidB (GABAB) …

GABAergic signaling is involved in modulating the reinforcing properties of alcohol, and
GABA B receptors have been proposed as a potential target for clinical treatment of …

The present paper summarizes experimental and clinical data indicating the therapeutic
potential of the GABAB receptor agonist, baclofen, in the treatment of alcohol use disorder …

Rationale Treatment with positive allosteric modulators (PAMs) of the GABA B receptor
(GABA B PAMs) inhibits several alcohol-motivated behaviors in rodents, including operant …