Background. Inflammatory responses induced by intestinal ischemia‐reperfusion (IIR) lead
to serious systemic organ dysfunction and pose a challenge for current treatment. This study …

Emerging evidence suggests that NLRP3 inflammasome was associated with various kinds
of immunological diseases including colitis. However, there are few drugs targeting …

NLRP3 inflammasome has been reported to be associated with inflammatory bowel disease
including colitis due to its potential ability to induce IL-1β secretion. Emerging studies have …

Background Intestinal ischemia-reperfusion injury (IIRI) is a common clinical event that can
cause serious consequences. The study aimed to investigated the effect of VX-765 in IIRI …

NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) inflammasome is a
component of innate immunity, and is responsible for producing mature IL-1β and-18 …

Previous studies reported that Ginsenoside Rd (Rd) had anti-inflammatory and anti-cancer
effects. However, the molecular mechanism underlying the inhibition effect of Rd on colitis in …

The NLRP3 inflammasome plays an important role in intestinal homeostasis as well as
inflammation. However, in vivo studies investigating the role of the NLRP3 inflammasome in …

Background Macrophages present strong immunomodulatory ability and are considered to
be core immune cells in the process of hepatic ischaemia‒reperfusion (I/R). The NLRP3 …

The inflammasome is a large, multiprotein complex that consists of a nucleotide-binding
oligomerization domain-like receptor (NLR), an apoptosis-associated speck-like protein …

Scope The NLRP3 inflammasome responds to various pathogen‐derived factors and
danger‐associated molecules, mediating IL‐1β maturation, therefore is involved in multiple …