While silica particles are considered to be fibrogenic and carcinogenic agents, the
mechanisms responsible are not well understood. This article summarizes literature on silica …

Silica particles are considered to be fibrogenic and carcinogenic agents, but the
mechanisms of disease initiation and progression are not fully understood. This article …

The inflammation and fibrosis induced by silica dust are considered to be substantial
responses in silicosis progression. Interleukin-1 beta (IL-1β) plays an important role in silica …

Silicosis is caused by the inhalation of crystalline silica (silicon dioxide, SiO2) in various
forms. This review proposes that the cascade of inflammatory and fibrotic events involved in …

Alveolar macrophages play a critical role in silica-induced lung fibrosis. Silica exposure
induces tumor necrosis factor (TNF)-α release and nuclear factor (NF)-κ B activation, and …

Inhalation of dust containing crystalline silica is associated with a number of acute and
chronic diseases including systemic autoimmune diseases. Evidence for the link with …

Crystalline silica has been shown to trigger pulmonary inflammation both in vivo and in vitro,
but the underlying molecular mechanisms remain unclear. In the present study we focus on …

Inhalation of silica particles is an environmental and occupational cause of silicosis, a type
of pneumoconiosis. Development of the lung silicosis is a unique process in which the …

Numerous investigations have been conducted to elucidate mechanisms involved in the
initiation and progression of silicosis. However, most of these studies involved bolus …

Crystalline silica exposure can result in pulmonary fibrosis, where the pulmonary
macrophage is key as a result of its ability to react to silica particles. In the mouse silicosis …