N-acetyl-L-cysteine protects against inhaled sulfur mustard poisoning in the large swine

B Jugg, S Fairhall, A Smith, S Rutter, T Mann… - Clinical …, 2013 - Taylor & Francis
Context. Sulfur mustard is a blister agent that can cause death by pulmonary damage. There
is currently no effective treatment. N-acetyl-L-cysteine (NAC) has mucolytic and antioxidant …

Epigenetic perturbations in the pathogenesis of mustard toxicity; hypothesis and preliminary results

A Korkmaz, H Yaren, Z Kunak, B Uysal, B Kurt… - Interdisciplinary …, 2008 - sciendo.com
Among the most readily available chemical warfare agents, sulfur mustard (SM), also known
as mustard gas, has been the most widely used chemical weapon. SM causes debilitating …

Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes

O Kumar, K Sugendran, R Vijayaraghavan - Chemico-biological …, 2001 - Elsevier
Protective effect of various antioxidants, trolox (water soluble analogue of vitamin E),
quercetin (bioflavonoid) and glutathione reduced (GSH), was studied following sulphur …

Dose-and time-dependent effects of sulfur mustard on antioxidant system in liver and brain of rat

M Jafari - Toxicology, 2007 - Elsevier
This study investigates the dose-and time-dependent effects of sulfur mustard (SM) on
antioxidant system and lipid peroxidation in liver and brain of rats. For this purpose, male …

Inflammatory mechanisms of pulmonary injury induced by mustards

R Malaviya, VR Sunil, A Venosa, KN Vayas, DE Heck… - Toxicology letters, 2016 - Elsevier
Exposure of humans and animals to vesicants, including sulfur mustard (SM) and nitrogen
mustard (NM), causes severe and debilitating damage to the respiratory tract. Both acute …

Editor's highlight: pulmonary vascular thrombosis in rats exposed to inhaled sulfur mustard

MD McGraw, CM Osborne, EJ Mastej… - Toxicological …, 2017 - academic.oup.com
Sulfur mustard (SM) is a chemical warfare agent. When inhaled, SM causes significant injury
to the respiratory tract. Although the mechanism involved in acute airway injury after SM …

Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice

U Wormser, R Langenbach, S Peddada… - Toxicology and applied …, 2004 - Elsevier
Sulfur mustard (SM), a potent vesicant and chemical warfare agent, induces tissue damage
involving an inflammatory response, including vasodilatation, polymorphonuclear infiltration …

Assessment of alterations in barrier functionality and induction of proinflammatory and cytotoxic effects after sulfur mustard exposure of an in vitro coculture model of …

J Emmler, MI Hermanns, D Steinritz, H Kreppel… - Inhalation …, 2007 - Taylor & Francis
Acute lung injury after sulfur mustard (SM) inhalation is characterized by massive, localized
hemorrhage and alveolar edema, which implies severe disruption of the vascular and distal …

Treatment of sulfur mustard (HD)‐induced lung injury

DR Anderson, SL Byers… - Journal of Applied …, 2000 - Wiley Online Library
An in vivo sulfur mustard (HD) vapor exposure model followed by bronchoalveolar lavage
was developed previously in this laboratory to study biochemical indicators of HD‐induced …

Mustard vesicant-induced lung injury: Advances in therapy

B Weinberger, R Malaviya, VR Sunil, A Venosa… - Toxicology and applied …, 2016 - Elsevier
Most mortality and morbidity following exposure to vesicants such as sulfur mustard is due to
pulmonary toxicity. Acute injury is characterized by epithelial detachment and necrosis in the …