N-acetyl-L-cysteine protects against inhaled sulfur mustard poisoning in the large swine
B Jugg, S Fairhall, A Smith, S Rutter, T Mann… - Clinical …, 2013 - Taylor & Francis
Context. Sulfur mustard is a blister agent that can cause death by pulmonary damage. There
is currently no effective treatment. N-acetyl-L-cysteine (NAC) has mucolytic and antioxidant …
is currently no effective treatment. N-acetyl-L-cysteine (NAC) has mucolytic and antioxidant …
Epigenetic perturbations in the pathogenesis of mustard toxicity; hypothesis and preliminary results
Among the most readily available chemical warfare agents, sulfur mustard (SM), also known
as mustard gas, has been the most widely used chemical weapon. SM causes debilitating …
as mustard gas, has been the most widely used chemical weapon. SM causes debilitating …
Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes
O Kumar, K Sugendran, R Vijayaraghavan - Chemico-biological …, 2001 - Elsevier
Protective effect of various antioxidants, trolox (water soluble analogue of vitamin E),
quercetin (bioflavonoid) and glutathione reduced (GSH), was studied following sulphur …
quercetin (bioflavonoid) and glutathione reduced (GSH), was studied following sulphur …
Dose-and time-dependent effects of sulfur mustard on antioxidant system in liver and brain of rat
M Jafari - Toxicology, 2007 - Elsevier
This study investigates the dose-and time-dependent effects of sulfur mustard (SM) on
antioxidant system and lipid peroxidation in liver and brain of rats. For this purpose, male …
antioxidant system and lipid peroxidation in liver and brain of rats. For this purpose, male …
Inflammatory mechanisms of pulmonary injury induced by mustards
Exposure of humans and animals to vesicants, including sulfur mustard (SM) and nitrogen
mustard (NM), causes severe and debilitating damage to the respiratory tract. Both acute …
mustard (NM), causes severe and debilitating damage to the respiratory tract. Both acute …
Editor's highlight: pulmonary vascular thrombosis in rats exposed to inhaled sulfur mustard
Sulfur mustard (SM) is a chemical warfare agent. When inhaled, SM causes significant injury
to the respiratory tract. Although the mechanism involved in acute airway injury after SM …
to the respiratory tract. Although the mechanism involved in acute airway injury after SM …
Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice
U Wormser, R Langenbach, S Peddada… - Toxicology and applied …, 2004 - Elsevier
Sulfur mustard (SM), a potent vesicant and chemical warfare agent, induces tissue damage
involving an inflammatory response, including vasodilatation, polymorphonuclear infiltration …
involving an inflammatory response, including vasodilatation, polymorphonuclear infiltration …
Assessment of alterations in barrier functionality and induction of proinflammatory and cytotoxic effects after sulfur mustard exposure of an in vitro coculture model of …
J Emmler, MI Hermanns, D Steinritz, H Kreppel… - Inhalation …, 2007 - Taylor & Francis
Acute lung injury after sulfur mustard (SM) inhalation is characterized by massive, localized
hemorrhage and alveolar edema, which implies severe disruption of the vascular and distal …
hemorrhage and alveolar edema, which implies severe disruption of the vascular and distal …
Treatment of sulfur mustard (HD)‐induced lung injury
DR Anderson, SL Byers… - Journal of Applied …, 2000 - Wiley Online Library
An in vivo sulfur mustard (HD) vapor exposure model followed by bronchoalveolar lavage
was developed previously in this laboratory to study biochemical indicators of HD‐induced …
was developed previously in this laboratory to study biochemical indicators of HD‐induced …
Mustard vesicant-induced lung injury: Advances in therapy
B Weinberger, R Malaviya, VR Sunil, A Venosa… - Toxicology and applied …, 2016 - Elsevier
Most mortality and morbidity following exposure to vesicants such as sulfur mustard is due to
pulmonary toxicity. Acute injury is characterized by epithelial detachment and necrosis in the …
pulmonary toxicity. Acute injury is characterized by epithelial detachment and necrosis in the …