A review on human fecal metabolomics: Methods, applications and the human fecal metabolome database

N Karu, L Deng, M Slae, AC Guo, T Sajed, H Huynh… - Analytica chimica …, 2018 - Elsevier
Metabolomic analysis of human biospecimens had progressed quickly over the past
decade. Technological and methodological advances have led to the comprehensive …

Metabolomics of fecal samples: a practical consideration

S Matysik, CI Le Roy, G Liebisch, SP Claus - Trends in Food Science & …, 2016 - Elsevier
Background Metabolic profiling is becoming increasingly popular to identify subtle metabolic
variations induced by diet alterations and to characterize the metabolic impact of variations …

Sample preparation optimization in fecal metabolic profiling

O Deda, AC Chatziioannou, S Fasoula… - … of Chromatography B, 2017 - Elsevier
Metabolomic analysis of feces can provide useful insight on the metabolic status, the
health/disease state of the human/animal and the symbiosis with the gut microbiome. As a …

Comparison of collection methods for fecal samples for discovery metabolomics in epidemiologic studies

E Loftfield, E Vogtmann, JN Sampson, SC Moore… - … Biomarkers & Prevention, 2016 - AACR
Background: The gut metabolome may be associated with the incidence and progression of
numerous diseases. The composition of the gut metabolome can be captured by measuring …

Fecal metabolomics: assay performance and association with colorectal cancer

JJ Goedert, JN Sampson, SC Moore, Q Xiao… - …, 2014 - academic.oup.com
Metabolomic analysis of feces may provide insights on colorectal cancer (CRC) if assay
performance is satisfactory. In lyophilized feces from 48 CRC cases, 102 matched controls …

[HTML][HTML] Metabolomics in human nutrition: opportunities and challenges

MJ Gibney, M Walsh, L Brennan, HM Roche… - The American journal of …, 2005 - Elsevier
Metabolomics has been widely adopted in pharmacology and toxicology but is relatively
new in human nutrition. The ultimate goal, to understand the effects of exogenous …

An overview of fecal sample preparation for global metabolic profiling

O Deda, HG Gika, ID Wilson, GA Theodoridis - Journal of pharmaceutical …, 2015 - Elsevier
The global metabolic profiling of feces represents a challenge for both analytical chemistry
and biochemistry standpoints. As a specimen, feces is complex, not homogenous and rich in …

Development of a quantitative metabolomic approach to study clinical human fecal water metabolome based on trimethylsilylation derivatization and GC/MS analysis

X Gao, E Pujos-Guillot, JL Sebedio - Analytical chemistry, 2010 - ACS Publications
Metabolomic analysis of human fecal water recently aroused increasing attention with the
importance of fecal metabolome in exploring the relationships between symbiotic gut …

Coupling targeted and untargeted mass spectrometry for metabolome-microbiome-wide association studies of human fecal samples

AV Melnik, RR da Silva, ER Hyde, AA Aksenov… - Analytical …, 2017 - ACS Publications
Increasing appreciation of the gut microbiome's role in health motivates understanding the
molecular composition of human feces. To analyze such complex samples, we developed a …

Challenges of metabolomics in human gut microbiota research

KS Smirnov, TV Maier, A Walker, SS Heinzmann… - International Journal of …, 2016 - Elsevier
The review highlights the role of metabolomics in studying human gut microbial metabolism.
Microbial communities in our gut exert a multitude of functions with huge impact on human …