Background Frailty is a risk factor for cardiovascular disease (CVD). Underlying mechanisms
to explain the connection between frailty and CVD are unclear. We sought to examine the …

Background/objectives Subclinical cardiovascular disease (CVD) is cross-sectionally
associated with frailty, but the relationship between subclinical CVD and incident frailty has …

Frailty and cardiovascular disease share some of the pathophysiologic features. Our
objective was to review and metaanalyse the available published evidence on the topic. We …

Purpose Frailty and atherosclerotic diseases are prevalent among the older people and
usually present the same pathogenesis and risk factors. Therefore, the aim of this study was …

Arterial stiffness, represented as carotid-femoral pulse wave velocity (cfPWV), predicts
cardiovascular disease (CVD). In older populations, however, this association seems …

Background Inflammation, coagulation activation, endothelial dysfunction and subclinical
vascular disease are cross-sectionally associated with frailty. Cardiac-specific biomarkers …

Background Prospective cohort studies suggest that frailty is associated with an increased
risk of incident cardiovascular disease (CVD) morbidity and mortality, but their mechanistic …

In frail older adults, low blood pressure (BP) might be associated with worse health
outcomes and hypertension management in this population is highly debated. Using data …

Background: Frailty is an important risk factor for cardiovascular disease (CVD), but the
impact of early, potentially reversible stages of frailty on CVD risk is unknown. Objectives …

Background: Factors that may contribute to the development of frailty in late life have not
been widely investigated. The Atherosclerosis Risk in Communities (ARIC) Study cohort …