Molecular genetic pathways as therapeutic targets in acute myeloid leukemia

T Haferlach - ASH Education Program Book, 2008 - ashpublications.org
The heterogeneity of acute myeloid leukemia (AML) results from a complex network of
cytogenetic aberrations and molecular mutations. These genetic markers are the basis for …

Genetic abnormalities and challenges in the treatment of acute myeloid leukemia

CC Kumar - Genes & cancer, 2011 - journals.sagepub.com
Acute myeloid leukemia (AML) is a hematopoietic disorder in which there are too many
immature blood-forming cells accumulating in the bone marrow and interfering with the …

Genomic applications in the clinic: use in treatment paradigm of acute myeloid leukemia

RF Schlenk, H Döhner - Hematology 2013, the American …, 2013 - ashpublications.org
In recent years, research in genomics has resulted in the rapid uncovering of the molecular
pathogenesis of acute myeloid leukemia (AML). The identification of the genetic …

Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach

F Mandelli, MC Petti, FL Coco - Haematologica, 1998 - haematologica.org
BACKGROUND AND OBJECTIVE: The successful use of differentiating treatment for
patients with acute promyelocytic leukemia (APL) suggests that other acute myeloid …

Current and emerging molecular and epigenetic disease entities in acute myeloid leukemia and a critical assessment of their therapeutic modalities

X Zhao, H Liu, LN Wang, L Yang, X Liu - Seminars in Cancer Biology, 2022 - Elsevier
Acute myeloid leukemia (AML) is the most frequently diagnosed acute leukemia, and its
incidence increases with age. Although the etiology of AML remains unknown, exposure to …

[HTML][HTML] The clinical impact of the molecular landscape of acute myeloid leukemia

S Kayser, MJ Levis - Haematologica, 2023 - ncbi.nlm.nih.gov
Research into the underlying pathogenic mechanisms of acute myeloid leukemia (AML) has
led to remarkable advances in our understanding of the disease. Mutations now allow us to …

Molecular changes during acute myeloid leukemia (AML) evolution and identification of novel treatment strategies through molecular stratification

E Karjalainen, GA Repasky - … in molecular biology and translational science, 2016 - Elsevier
Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by impaired
differentiation and uncontrollable proliferation of myeloid progenitor cells. Due to high …

The evolving molecular genetic landscape in acute myeloid leukaemia

MA Sanders, PJM Valk - Current opinion in hematology, 2013 - journals.lww.com
The list of acquired mutations with clinical value in AML is growing. Clinical implementation
of this multitude of markers will require integrated approaches and selection of markers to …

Impact of genetic features on treatment decisions in AML

H Döhner, VI Gaidzik - Hematology 2010, the American Society …, 2011 - ashpublications.org
In recent years, research in molecular genetics has been instrumental in deciphering the
molecular pathogenesis of acute myeloid leukemia (AML). With the advent of the novel …

Descriptive and functional genomics in acute myeloid leukemia (AML): paving the road for a cure

H Pasquer, M Tostain, N Kaci, B Roux, L Benajiba - Cancers, 2021 - mdpi.com
Simple Summary Acute myeloid leukemia (AML) accounts for 7.6% of hematopoietic
malignancies with a long-term survival of less than 20%. Better understanding its …